Active and Passive Avoidance Test
The avoidance experiment is a classical joint learning conditioned reflex commonly used to test the learning memory ability of animals. The avoidance experiment took advantage of rodents' habits of loving dark environments and aversing stimuli.
According to the different ways of escape after the animal is stimulated, it is divided into active avoidance and passive avoidance. Experiments designed according to this principle include shuttle experiments, jumping table experiments, dark avoidance experiments, etc.
Our company offers a wide range of active and passive avoidance tests, and is committed to providing professional behavioral testing methods for learning and memory to help our customers innovate in neuroscience and neuropharmacology research.
Features of Avoidance Experiments
- Simple and easy to operate experiments
- The results are easy to discern and highly credible
- It can be used either as a stand-alone test experiment to provide subject parameters or as an adjunct or pre-screening experiment to other learning memory and cognitive function experiments.
Examples of Experimental Cases (Shuttle Box Test)
Experimental Principle
Fig. 1 Shuttle box.
Experimental Flow
- Adaptation period
two days before the test, pet the experimental animals for 1-5 min to eliminate animal fear.
- Training period
The animals were free to move around for 5 min, and then placed in the electric shock area after familiarizing with the test environment. After 20s of light stimulation, 10s of electrical stimulation was given. The experimental animals fled to the safe area within 20s of the light for active avoidance, and fled to the safe area only after the electric shock for passive avoidance, and were trained 20-40 times.
- Testing period
The experimental animals were placed in the electric shock area, and the method was the same as the training period. The number of active avoidance and the number of passive avoidance of the experimental animals were recorded.
Experimental Indexes
| Indexes | Description |
|---|---|
| Observing time | Total time of animal activity in the experimental chamber |
| Active avoidance time | Number of times animals escaped to the safety zone during the light sound occurrence after the experiment started |
| Passive avoidance time | Number of times the animal was electrically stimulated to evade and escape to a safe area |
| Active avoidance average response time | Each time the time from the start of the light or sound to the occurrence of active evasion, the cumulative total is divided by the number of active evasions to obtain the value |
| Passive aoidance average response time | The value is obtained by dividing the cumulative sum of the time from the start of each electrical stimulation to the occurrence of passive avoidance by the number of passive avoidance |
| Other indexes (Number of non-response, active avoidance latency, passive avoidance latency) | |
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