Animal Models of Psychiatric Diseases
Psychiatric diseases are a highly genetic, polygenic and complex group of diseases with extremely high disability rates that place a huge burden on the world economy and disease treatment. Animal models of psychiatric diseases are useful tools for screening new drugs and studying the mechanisms of these diseases.
Our company combines our specialized behavioral testing methods with neurological psychiatric disorders. We are committed to providing valid and sound behavioral assessments of our clients' models of psychiatric diseases to facilitate advances in relevant disease mechanisms and therapeutic approaches.
Overview of Psychiatric Diseases
Psychiatric diseases are often caused by a combination of factors. Usually under the influence of genetic, psychological and environmental factors, brain dysfunction leads to varying degrees of impairment in the individual's mental activities such as cognition, emotion, behavior and social skills. Due to the lack of fundamental understanding of the mechanisms underlying this type of disease, it is often difficult for researchers to investigate emotional, psychiatric, and environmentally induced disease mechanisms at the most basic level.
Fig. 1 Different approaches to constructing models for psychiatric disorders. (Nani, 2019)
Psychiatric Diseases Animal Models We Provide
As the genetic mechanisms of psychiatric diseases have been extensively studied, genetic animal models of psychiatric disorders have received increasing attention and high expectations. Despite the difficulty of simulating human psychiatric disorders in animals, a series of animal models of depression, schizophrenia and other related disorders have been successfully developed. These models provide good insights in the study of the etiopathology as well as the therapeutic mechanisms of psychiatric disorders.
Our company offers the following animal services, providing a wide range of animal disease models as well as animal behavioral testing services.
Model Evaluation of Psychiatric Diseases
The ideal disease model needs to satisfy the consistency of etiology and pathology with human diseases while simulating the core symptoms of the disease well. Behavioral science plays a crucial role by identifying specific symptoms in animal models of these human diseases. Our company has established various objective evaluation tools to evaluate the corresponding disease models.
| Behavior | Testing Methods | ||
|---|---|---|---|
| Cognitive | Morris water maze test | Barnes maze test | Radial arm maze test |
| Y-maze test | T-maze test | 5-CSRTT test | |
| Touch screen test | |||
| Anxiety | Elevated plus maze test | Open field test | Light-dark box test |
| Sucrose preference test | Forced swimming test | Tail suspension test | |
| Social | Three-chamber test | Social interactions test | |
| Motor | Beam test | Rotarod test | General locomotor test |
| Gait analysis test | Pole test | Rearing cylinder test | |
| Ladder rung walking test | |||
Advantages of Our company
- We provide one-stop service, from protocol customization, animal modeling to follow-up animal behavior evaluation, providing you with a complete service process.
- We have an experienced animal experimentation team, which strictly controls every step of animal modeling and model evaluation, and is committed to providing ideal experimental models for our customers.
- We assist you with project execution, data validation and generation of final reports.
Our company is committed to combining our specialized experimental platform and extensive scientific knowledge to jointly provide effective research models for the development of the field of neuroscience. If you are interested, please contact us and describe your specific research, and we will be happy to assist you.
Reference
- Nani, J.; et al. Animal Models in Psychiatric Disorder Studies. Animal Models in Medicine and Biology. 2019. 10.5772/intechopen.89034.