Brain Injury Caused by Accidental Injury
The incidence of traumatic brain injury due to accidental injury is increasing year by year, bringing about numerous economic, medical and other social problems. Our company provides a variety of scientifically reliable evaluation methods for exploring the mechanisms of brain injury and the behavioral changes that occur after injury.
Introduction of Traumatic Brain Injury
Car accidents, crashes or other accidental injuries often result in traumatic brain injury in individuals and are one of the leading causes of disability and death worldwide. Depending on the extent of the injury, there are mild, moderate and more severe brain injuries. The impact on individuals involves multiple physical and psychological aspects, which seriously impairs the physical health and quality of life of the injured.
Fig. 1 Main pathophysiological mechanisms underlying pituitary damage after TBI. (Gasco, 2021)
Effects of Traumatic Brain Injury on The Brain
The brain is the most advanced part of the nervous system, and injury to specific parts of it can lead to dysfunction of the corresponding brain regions. Injuries to the brain from external forces and other factors often result in a range of dysfunctions. For example, injury to the parietal lobe can lead to a lack of muscle strength, injury to the brainstem can affect an individual's ability to speak, and injury to the frontal lobe can lead to a range of behavioral problems. In addition, traumatic brain injury can also cause a variety of hidden injuries, such as long-term and short-term memory damage, personality, mood and other changes.
Behavioral Changes Due to Traumatic Brain Injury
Traumatic brain injuries cause a wide range of injuries to individuals. Some symptoms appear immediately after the injury, some may occur after a while, and the combination of multiple symptoms may affect an individual's normal functioning for a long time.
Specific effects of traumatic brain injury on individuals include
| Symptoms Caused by Traumatic Brain Injury | |||
|---|---|---|---|
| Change of awareness |
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Movement disorders |
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| Cognitive disorders |
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Behavior changes |
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| Emotional changes |
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Degenerativ brain diseases | Repeated or severe brain injuries can increase the risk of degenerative brain diseases, including
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Traumatic Brain Injury Model Evaluation
Traumatic brain injury often leads to sensory and cognitive impairments. Our company has developed several behavioral assessment methods that can be used in experimental animal models of traumatic brain injury to assess different aspects of clinically relevant behavior.
| Behavior | Testing Methods | ||
|---|---|---|---|
| Cognitive | Morris water maze test | Barnes maze test | Radial arm maze test |
| Y-maze test | T-maze test | 5-CSRTT test | |
| Touch screen test | |||
| Anxiety | Elevated plus maze test | Open field test | Light-dark box test |
| Sucrose preference test | Forced swimming test | Tail suspension test | |
| Social | Three-chamber test | Social interactions test | |
| Motor | Beam test | Rotarod test | General locomotor test |
| Gait analysis test | Pole test | Rearing cylinder test | |
| Ladder rung walking test | |||
Our companyspecializes in providing appropriate animal models and behavioral assessment methods for the study of traumatic brain injury caused by car accidents, crashes, and other accidental injuries. We have a wealth of experience, a wide range of services and the research methods you need. If you are interested, please contact us and describe your specific research, and we will be happy to assist you.
Reference
- Gasco, V.; et al. Traumatic brain injury as frequent cause of hypopituitarism and growth hormone deficiency: epidemiology, diagnosis, and treatment. Frontiers in endocrinology. 2021, 12: 634415.