Injuries Caused by Brain Atrophy
Brain atrophy is a neurological disorder whose occurrence affects the normal life and work of human beings. Our company has advanced technology and proven testing methods in disease model evaluation, and we focus on providing our clients with a variety of scientifically designed and validated methods for testing animal behavior and solutions for brain injury research.
Introduction of Brain Atrophy
Brain atrophy is usually caused by aging, brain injury, neurological disease or infectious disease, and is a disease of the central nervous system due to organic lesions of brain tissue. Pathologically, it shows a reduction in the volume of brain tissue, a decrease in the number of cells, and an enlargement of the ventricles and subarachnoid space.
Fig. 1 Comparison of normal brain and brain atrophy.
Clinical Manifestations of Brain Atrophy
The main manifestations of brain atrophy are divided into two categories: brain function decline and cognitive decline, which are mainly related to the location and degree of brain atrophy.
| Diffuse cortical atrophy | Dementia, mental retardation, memory impairment, personality changes, and behavioral disorders. |
| Focal brain atrophy | Mainly character behavior change. |
| Cerebellar atrophy | Mainly speech disorders, limb ataxia and intentional tremor. |
- Memory Disorders
Memory deficits often occur early in life, with progressive and complete memory loss as the disease progresses.
- Emotional Disorders
Personality change is often an early symptom, with impatience and social interaction disorders.
- Cognitive Disorders
Patients show an overall decline in intellectual activities such as comprehension, judgment, and computational skills, and are unable to adapt to social life and have difficulty performing work and household chores.
- Behavioral Disorders
Impaired physical coordination and even seizures or tremors.
Behavioral Tests in Rodents Models of Brain Atrophy
The use of rodent animal models of disease provides an effective strategy for research on aspects of brain atrophy. As described below, Our company offers a variety of behavioral approaches that can be used in animal models of brain atrophy to assess different aspects of clinically relevant behavior.
| Behavior | Testing Methods | ||
|---|---|---|---|
| Cognitive | Morris water maze test | Barnes maze test | Radial arm maze test |
| Y-maze test | T-maze test | 5-CSRTT test | |
| Touch screen test | |||
| Anxiety Anxiety | Elevated plus maze test | Open field test | Light-dark box test |
| Sucrose preference test | Forced swimming test | Tail suspension test | |
| Social | Three-chamber test | Social interactions test | |
| Motor | Beam test | Rotarod test | General locomotor test |
| Gait analysis test | Pole test | Rearing cylinder test | |
| Ladder rung walking test | |||
Our company specializes in providing appropriate animal models and behavioral assessment methods for research related to cognitive memory as well as motor disorders caused by brain atrophy. We have a wealth of experience, a wide range of services and the research methods you need. If you are interested, please contact us and describe your specific research, and we will be happy to assist you.