Fish Models
Fish Models as An Indispensable Tool in Biomedical Research
Fish, especially zebrafish, have become the fastest growing segment of research populations. They have become indispensable tools in biomedical research. Fish model used in biomedical research include zebrafish, medaka, killifish, swordtail fish, cavefish, Stickleback, goldfish, and Danionella translucida. Among them, zebrafish is the most commonly used fish model, and its transparent embryos and rapid growth make it ideal for studying genetics, toxicology, pharmacology, and cancer. In addition to this, zebrafish are popular among scientists because they share about 70% genetic similarity with humans.
What Fields of Scientists Benefit from Fish Model?
- Gene mutation studies. The transparent ectoderm of zebrafish makes it easy to observe its development in real time and allows rapid screening for specific gene mutations.
- High-throughput drug screening and testing. Because of their small size, short life cycle, and rapid reproduction, experimental fish allow for rapid and efficient large-scale drug screening and testing.
- Disease modeling. Many human diseases can be replicated in experimental fish, which in turn allows for the study of their pathogenesis, disease processes, and potential therapeutic strategies.
- Developmental biology research. Embryonic development in experimental fish (especially zebrafish) is rapid, with the first cell divisions of the embryo observed within a few hours. This makes them ideal models for studying developmental biology.
- Cellular and molecular biology studies. Using transgenic technology, it is possible to visualize the expression patterns of specific genes, cell migration pathways, etc. in experimental fish.
- Gene editing applications. Gene editing technology is widely used in experimental fish, allowing researchers to insert, repair, or knock out specific genes precisely.
- Behavioral studies. Because experimental fish can adapt and demonstrate a range of complex behaviors in a laboratory environment, such as learning behavior, memory, social behavior, etc.
What Disease Areas Does Our Lab Fish Support?
| Cardiovascular Diseases | Duchenne Muscular Dystrophy | Inflammatory Diseases |
| Kidney Diseases | Neurological Diseases | Bone Diseases |
| Eye Diseases | Blood Diseases | Liver Diseases |
| Tumors | Hearing Related Diseases | Regenerative |
| Metabolic Diseases | Infectious Diseases | Skeletal Diseases |
Related Models
Browse our list of fish models
| Models Name | Cat.No. | Animal Type | Disease Area |
|---|---|---|---|
| Bardet-Biedl syndrome, Glis2a knockout, in zebrafish | AB236582 | zebrafish | Bardet-Biedl syndrome |
| Basal cell nevus syndrome, Ptch2 mutated, in zebrafish | AB236583 | zebrafish | Basal cell nevus syndrome |
| Bethlem myopathy, Col6a1 mutated, in zebrafish | AB236584 | zebrafish | Bethlem myopathy |
| Biliary atresia, biliatresone-induced, in zebrafish | AB236585 | zebrafish | Atresia,biliary |
| Bladder cancer, patient-derived xenograft (Bladder cancer cells, human), in zebrafish | AB236586 | zebrafish | Cancer,bladder |
| Blindness, nup93 mutated, in zebrafish | AB236587 | zebrafish | Blindness |
| Bon marrow failure, parn knockdown, in zebrafish | AB236588 | zebrafish | Bone marrow failure |
| Bone (craniofacial) growth abnormalities, in zebrafish | AB236589 | zebrafish | |
| Bone disorders, Csf1ra knockout, in zebrafish | AB236590 | zebrafish | Bone disorders |
| Bone disorders, idh1/Idh2 mutated, in zebrafish | AB236591 | zebrafish | Bone disorders |