Novelty-Suppressed Feeding Test

Decreased interest in food intake is one of the common manifestations of depression. Novelty-suppressed feeding test is a typical behavioral test method that uses loss-of-interest behaviors to assess depression.

Our company is committed to providing professional, efficient novelty-suppressed feeding test using interest deficit-based behavioral testing methods to support our customers' innovative research in depression.

Experimental Principle

In novel environments, fasting animals exhibit reduced appetite for food in response to depression-like conflicts. If the experimental animals were in a state of anxiety, the time to start feeding in the novel environment was prolonged. The degree of depression can be assessed by observing and recording the latency of feeding in experimental animals.

Fig. 1 Novelty-suppressed feeding test.

Experimental Flow

• Pre-experiment preparation

Fasting the experimental animals for 24h.

An open field with a fixed area was used as a test device, with the bottom covered with bedding and several regularly shaped food items placed evenly.

• Testing Phase

The experimental animals were transferred from the breeding box to the test environment and placed into the experimental set-up one by one with their heads facing outward from one corner.

The latency to observe the feeding of experimental animals was recorded using the animal behavior analysis system.

Experimental Indicators

The latency period of ingestion of experimental animals was used as a criterion for detection. Ingestion was judged by the start of food chewing by the animal.

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