Microbiome therapeutics involve the transplantation of microorganisms to address underlying dysbiosis and reinforce normal microbiota functions to prevent, treat, or alleviate diseases. Leveraging expertise, innovation, and cutting-edge technology, our company is at the forefront of innovative drug development for gastrointestinal diseases and provides comprehensive solutions for developing microbiome therapeutics for rare gastrointestinal diseases.

Overview of Microbiome Therapeutics

The gastrointestinal microbiota is crucial in maintaining health, including metabolic balance, immune support, and nutrient absorption. Dysbiosis in the gut microbiota is associated with various rare gastrointestinal disorders. Microbiome therapeutics focus on adjusting the gut microbiome's composition and function to impact disease outcomes positively.

Physiological mechanisms of microbial therapeutics can be direct, involving the administered material, or indirect, affecting host factors and metabolic changes from the new microbial community. These mechanisms enhance colonization resistance and restore immune function and metabolites. Advancements in microbiota research, including next-generation sequencing and metabolomic analysis, have expanded the scope of microbiome therapy investigations. Microbiome therapy for several rare gastrointestinal diseases has been explored presently:

Fig.2 Key mechanisms of microbiome therapeutics. (Allegretti, J. R., et al., 2024)

Our Services

Centered on harnessing state-of-the-art research and pioneering methodologies, our commitment lies in advancing the field of microbiome therapeutics for rare gastrointestinal diseases. By integrating the most recent breakthroughs in microbiome science, we aim to provide inventive and impactful solutions that enable a comprehensive comprehension of the microbiome and foster advancements in your gastrointestinal disease research.

Personalized Microbiome Therapy Development Services

Target Identification

Identify specific microbial imbalances or dysbiosis associated with a particular condition.

Therapeutic Design

Develop microbiome-based therapies customized to address specific diseases.

In Vitro Validation

Conduct in vitro assays to assess the pharmacological attributes of microbiome therapeutics.

In Vivo Validation

Assess the safety and efficacy of manipulating the microbiome in disease models.

Types of Microbiome Therapeutics

Our company is committed to providing microbiome therapeutic development services to accelerate the development of safer and more effective microbiome therapeutics for rare gastrointestinal diseases. We provide customers with access to technological and scientific expertise, platforms, and networks aimed at supporting their projects and assessing the safety and effect of microbiome-based therapeutics.

If you are interested in our services, please feel free to contact us for further information and quotations on our services.

References

• Young, Remy B et al. "Key Technologies for Progressing Discovery of Microbiome-Based Medicines." Frontiers in microbiology 12 (2021): 685935.
• Allegretti, Jessica R et al. "The Progression of Microbiome Therapeutics for the Management of Gastrointestinal Diseases and Beyond." Gastroenterology 167.5 (2024): 885-902.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.