Antiparasitic drugs are important medicine to treat parasitic infections. Our company focuses on developing new antiparasitic drugs. We have a skilled research team together with advanced technology so we are in the position to help you find suitable drug candidates for a certain parasite and also speed up the process of commercialization of your research.
What are Antiparasitic Drugs?
Antiparasitic drugs are a group of drugs which have been given the purpose of dealing with infections caused by a variety of parasites. For instance, parasitic ailments that are caused by helminths, amoeba, parasitic fungi and even protozoa can be cured with the help of antiparasitic drugs.
Fig. 1 Mechanism of miltefosine in the treatment of Leishmania infection. (Dorlo T P C, et al., 2012)
How Do Antiparasitic Drugs Work in the Body?
The distinctive action mechanism of antiparasitic drugs is dependent both on the type of target parasite and on the drug that is being used. The antiparasitic drugs have several modes of action which include the following:
Disruption of Metabolic Pathways
Certain antiparasitic medications target particular enzymes or metabolic pathways within certain parasites thereby preventing their further growth as well as replication.
Alteration of Cellular Membrane Integrity
The aim of some antiparasitic medicine is to damage either the cell membrane of the parasite or its functional abilities. As a result, some important cellular processes are disarrayed leading to the death and elimination of the parasitic organism.
Interference with DNA Synthesis
Some anti-parasitic drugs work by targeting the enzymes the parasites use to replicate their DNA. This renders the parasites incapable of growing or reproducing within the host body.
Modulation of Neurotransmission
Some parasite medicines can block the parasite from doing key functions resulting in it's death or paralysis by blocking neurotransmission or blocking certain ion channels or receptors.
Classic Drugs for Parasitic Infections
A wide range of antiparasitic medications have been sanctioned following appropriate experimentation as well as extensive research assessment. Here are some classic antiparasitic medications:
| Antiparasitic Drugs |
Targets |
Mechanism |
Indications |
| Nitazoxanide |
Enzyme pyruvate |
Disruption of metabolic pathways |
Multiple parasitic infections, such as Cryptosporidium parvum, Giardia lamblia, and Entamoeba histolytica |
| Melarsoprol |
Melarsen oxide |
Disruption of metabolic pathways |
Trypanosoma brucei gambiense |
| Metronidazole |
DNA helix |
Interference with DNA synthesis and replication |
Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia |
| Tinidazole |
DNA helix |
Interference with DNA synthesis and replication |
Trichomonas vaginalis, Giardia lamblia, and Entamoeba histolytica |
| Albendazole |
β-tubulin subunit |
Disruption of metabolic pathways |
Roundworms, hookworms, whipworms, and tapeworms |
Our Services
The creation of antiparasitic medications has transformed the treatment of parasitic diseases, presenting viable options. Consistent with our goal of alleviating the world's parasitic disease burden, our company has also directed its efforts towards the research and development of new antiparasitic drugs. In partnership with us, you will get strong assistance in speeding up your research activities on antiparasitic drug development.
Workflow of Antiparasitic Drug Development
Applicable Disease Types
- Amoebiasis
- Anisakiasis
- Ascariasis
- Taeniasis
- Toxoplasmosis
- Trichinosis
- Babesiosis
- Balantidiasis
- Blastocystosis
- Dientamoebiasis
- Diphyllobothriasis
- African Trypanosomiasis
- Fasciolopsiasis
- Filariasis
- Giardiasis
- Malaria
- Trichomoniasis
- And More
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Dorlo T P C, Balasegaram M, Beijnen J H, et al. Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis[J]. Journal of Antimicrobial Chemotherapy, 2012, 67(11): 2576-2597.
- Dziduch K, Greniuk D, Wujec M. The current directions of searching for antiparasitic drugs[J]. Molecules, 2022, 27(5): 1534.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
