In order to understand the disease better and formulate appropriate therapeutic methods, animal models are essential. Ideally, an animal model must encompass a range of features of human mitochondrial diseases.
Our Services
Protheragen offers a comprehensive platform and features a wide spectrum of invertebrates and vertebrate animals in its animal models development service with a focus on solving the issues of mitochondrial disorder, which helps in the conduct of fundamental as well as preclinical applications.
Invertebrate Models
The utilization of various Invertebrate Models has proven to be indispensable in the investigation of mitochondrial disease.
Caenorhabditis elegans (C. elegans)
Advantages
- Rapid 3-day developmental cycle, facilitating efficient studies.
- Isogenic offspring and a 2-week lifespan allow economical large-scale experiments.
Applications
- Useful for characterizing global sequelae of mitochondrial dysfunction.
Drosophila Melanogaster (Fruit Fly)
Advantages
- High genetic conservation with mammals.
- Effective in studying mitochondrial disease states caused by mtDNA and nuclear gene mutations.
Applications
- Models available for various mitochondrial diseases, providing insights into tissue-specific pathology.
Vertebrate Models
The manifestation and severity of symptoms within each of these vertebrate model types are influenced by multiple factors, including the animal's genetic composition, age, as well as hormonal and environmental variables.
Danio Rerio (Zebrafish)
Advantages
- Rapid development, regular large offspring production, and cost-effective maintenance.
- High genetic homology to mammals, making it a valid model for human mitochondrial pathology.
- Possesses key organ systems, allowing the study of organ-specific mitochondrial pathology.
Applications
- Valuable for studying motor neuron diseases, myopathy, neuropathy, and cognitive endpoints.
- Direct in vivo visualization of organ systems and mitochondria.
Mouse Models
Advantages
- Precise genetic manipulation facilitates the study of specific mutations associated with mitochondrial diseases.
- Significant physiological and genetic similarities with humans make mice valuable for studying mitochondrial diseases.
- Reproducibility allows for experiments under controlled conditions and consistent results.
Applications
- Testing potential therapeutics including pharmacological agents and gene therapy.
Our Advantages
Professional Team
Advanced Technology
Comprehensive Services
Reliable Data and Results
The services for the development of the animal model encompass an extensive range of models, which ensures thorough and structured research. We apply detailed and replicable methods from intervention formulation through to dosing and bioavailability. This attention to detail assures that our animal models effectively inform research efforts, thus facilitating the development of precise interventions for mitochondrial disorders. Please contact us if you are interested in our services.
Reference
- Tolle, I., et al., (2023). Modeling mitochondrial DNA diseases: from base editing to pluripotent stem-cell-derived organoids. EMBO reports, 24(4), e55678.
