Animal models are indispensable for gaining a deeper understanding of the pathophysiology and developing effective therapeutic strategies. Ideally, an animal model should replicate a range of symptoms observed in human mitochondrial diseases.
Our Services
Protheragen offers a comprehensive platform to bridge the gap between basic research and clinical applications, providing an animal models development service that utilizes a diverse range of invertebrate and vertebrate model organisms to effectively address the intricacies associated with mitochondrial dysfunction.
Invertebrate Models
The utilization of various Invertebrate Models has proven to be indispensable in the investigation of mitochondrial disease.
Caenorhabditis elegans (C. elegans)
Advantages
- Rapid 3-day developmental cycle, facilitating efficient studies.
- Isogenic offspring and a 2-week lifespan allow economical large-scale experiments.
Applications
- Useful for characterizing global sequelae of mitochondrial dysfunction.
Drosophila Melanogaster (Fruit Fly)
Advantages
- High genetic conservation with mammals.
- Effective in studying mitochondrial disease states caused by mtDNA and nuclear gene mutations.
Applications
- Models available for various mitochondrial diseases, providing insights into tissue-specific pathology.
Vertebrate Models
The manifestation and severity of symptoms within each of these vertebrate model types are influenced by multiple factors, including the animal's genetic composition, age, as well as hormonal and environmental variables.
Danio Rerio (Zebrafish)
Advantages
- Rapid development, regular large offspring production, and cost-effective maintenance.
- High genetic homology to mammals, making it a valid model for human mitochondrial pathology.
- Possesses key organ systems, allowing the study of organ-specific mitochondrial pathology.
Applications
- Valuable for studying motor neuron diseases, myopathy, neuropathy, and cognitive endpoints.
- Direct in vivo visualization of organ systems and mitochondria.
Mouse Models
Advantages
- Precise genetic manipulation facilitates the study of specific mutations associated with mitochondrial diseases.
- Significant physiological and genetic similarities with humans make mice valuable for studying mitochondrial diseases.
- Reproducibility allows for experiments under controlled conditions and consistent results.
Applications
- Testing potential therapeutics including pharmacological agents and gene therapy.
Our Advantages
Professional Team
Advanced Technology
Comprehensive Services
Reliable Data and Results
Our animal model development service integrates a wide range of model systems, ensuring comprehensive and cohesive research. We employ rigorous and reproducible methodologies that take into account various factors such as intervention formulation, dosing, and bioavailability. This meticulous approach guarantees that the knowledge acquired from our animal models effectively informs research efforts, thereby contributing significantly to the development of targeted therapies for mitochondrial diseases. If you are interested in our services, please don't hesitate to contact us.
Reference
- Tolle, I., et al., (2023). Modeling mitochondrial DNA diseases: from base editing to pluripotent stem-cell-derived organoids. EMBO reports, 24(4), e55678.
