The invention of a suitable drug delivery system is critical for effective therapy, owing to the complexities relating to the particular bilayer architecture of the mitochondria, which block the therapeutic agents from penetrating deep within. Protheragen is focused on improving the pharma delivery systems to make the drug development cycle for mitochondrial disorders more efficient.
Understanding Drug Delivery Systems for Mitochondrial Diseases
Therapeutic targets mitochondria are difficult to exploit because molecules are hard to deliver to their designed sites. A particular aspect that accounts for this problem is the permeability of the mitochondria membranes. For example, the outer mitochondrial membrane (OMM) is characterized by a greater transition pore, which allows effortless movement of therapeutic agents. Conversely, the inner mitochondrial membrane (IMM) has unique characteristics such as membrane potential, lipophilicity, specific proteins for import, and a unique phospholipid. Targeted drug delivery is difficult because of the unique structures in mitochondria.
Fig.1 Different strategies for mitochondria-targeted drug delivery. (Khan, T., et al., 2022)
Our Services
Protheragen has an adept research team for the design and development of drug delivery systems. Our capabilities in drug delivery systems development seek new ways and customize personalized strategies to enable more precise therapeutic agent targeting to the mitochondria by overcoming the obstacles peculiar to mitochondrial membranes. We provide the following services.
Small Lipophilic Cationic Molecules-Based Drug Delivery Services
Use small compounds like Triphenylphosphonium Cation (TPP+), Rhodamine, and Pyridinium Salts to carry out drug-targeting delivery by changing the potential across the inner mitochondrial membrane.
Mitochondria-Targeting Signal Peptides-Based Drug Delivery Services
Design and develop signaling peptides with particular amino acid sequences that enable the translocation of nuclear-encoded mitochondrial proteins to the mitochondria for DNA or gene delivery.
Cardiolipin Targeting (Penetrating Peptides)-Based Drug Delivery Services
Implement an innovative approach for targeted drug delivery through a particular peptidyl delivery system. Many cell-penetrating peptides possess the ability to traverse the mitochondria membrane.
Nanoparticle (NPs)-Based Drug Delivery-Based Drug Delivery Services
Utilize liposomes, polymer nanoparticles, and inorganic nanoparticles as carriers for mitochondrial targeting drug delivery systems through surface modification and drug encapsulation.
Our Advantages
- Enhanced technology
Utilizing cutting-edge scientific advancements and research findings to develop targeted drug delivery systems for mitochondria.
- Tailored solutions
Providing bespoke solutions in drug delivery systems about a customer's needs for the best therapy results.
- Interdisciplinary expertise
A multi-disciplinary group, which includes chemists, biologists, pharmacists, etc., works seamlessly for the successful implementation of projects.
- Rigorous quality control
Compliance with global and local standards and regulations is adhered to ensure the safety and effectiveness of the drug delivery systems.
Should our service interest you, or if you would like to make any inquiries, please contact us. We will gladly provide you with consulting services and tailor an adequate solution to your needs.
Reference
- Khan, T., et al., (2022). Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches. Pharmaceutics, 14(12), 2657.
