The development of an effective drug delivery approach is crucial for mitochondria-targeted therapy, given the challenges posed by the unique bilayer structure of mitochondria that hinder therapeutic molecules from reaching the core. Protheragen is committed to advancing drug delivery systems to expedite the drug development process for mitochondrial diseases.
Understanding Drug Delivery Systems for Mitochondrial Diseases
The primary challenge in exploiting mitochondria as a therapeutic target lies in effectively delivering therapeutic molecules to their intended destination. One key factor contributing to this challenge is the differential permeability of the mitochondrial membranes. While the outer mitochondrial membrane (OMM) features a wider transition pore that facilitates easy traversal of therapeutic molecules, the inner mitochondrial membrane (IMM) possesses unique properties such as membrane potential, lipophilicity, specialized protein import machinery, and distinctive phospholipid composition. Due to the unique characteristics of mitochondria, achieving targeted drug deliver is challenging.
Fig.1 Different strategies for mitochondria-targeted drug delivery. (Khan, T., et al., 2022)
Our Services
For the design and development of drug delivery systems, Protheragen boasts an experienced research team. Our drug delivery systems development service is dedicated to formulating innovative strategies that effectively surmount barriers unique to mitochondrial membranes, thereby augmenting the targeted delivery of therapeutic agents to mitochondria. The services we provide are as follows.
Small Lipophilic Cationic Molecules-Based Drug Delivery Services
We employ small molecules such as Triphenylphosphonium Cation (TPP+), Rhodamine, and Pyridinium Salts to achieve targeted drug delivery by modulating the potential difference across the mitochondrial inner membrane, offering a potential therapeutic approach for treating diseases associated with mitochondrial oxidative stress.
Mitochondria-Targeting Signal Peptides-Based Drug Delivery Services
We design signaling peptides based on specific amino acid sequences to facilitate the translocation of nucleo-encoded mitochondrial proteins into mitochondria, thereby enabling DNA or gene delivery to the mitochondria.
Cardiolipin Targeting (Penetrating Peptides)-Based Drug Delivery Services
We utilize a specific peptidyl delivery system to establish an innovative pathway for targeted drug delivery. Numerous cell-penetrating peptides possess the ability to traverse the mitochondrial membrane.
Nanoparticle (NPs)-Based Drug Delivery-Based Drug Delivery Services
We employ liposomes, polymer nanoparticles, and inorganic nanoparticles as drug delivery systems for targeted mitochondrial delivery through surface modification and drug encapsulation.
Our Advantages
- Enhanced technology
Utilizing cutting-edge scientific advancements and research findings to develop targeted drug delivery systems for mitochondria.
- Tailored solutions
Providing customized drug delivery solutions based on individual customer requirements to achieve optimal treatment outcomes.
- Interdisciplinary expertise
A team of professionals from diverse fields such as chemistry, biology, pharmacy, etc., collaborates seamlessly to ensure successful project implementation.
- Rigorous quality control
Adhering strictly to international standards and specifications in order to guarantee the safety and efficacy of drug delivery systems.
If you are interested in our service or have any inquiries, please do not hesitate to contact us. We will be delighted to offer you consulting services and customize the optimal solution for your needs.
Reference
- Khan, T., et al., (2022). Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches. Pharmaceutics, 14(12), 2657.
