The brain’s sophisticated architecture and its heightened energy demand make it vulnerable to deficiencies in mitochondrial oxidative phosphorylation. Therefore, neurodegeneration is considered one of the hallmarks of mitochondrial diseases. Protheragen knows how important precise and complete neuroimaging services are for deepening the knowledge and developing therapeutics for mitochondrial diseases. We offer specialized insights into the neuroimaging aspects of these diseases through our neuroimaging service.
Applications of Neuroimaging in Mitochondrial Disease
The mitochondrial oxidative phosphorylation system (OXPHOS) plays a crucial role in meeting the majority of energy demands in the central nervous system (CNS). Consistent with the pivotal function of OXPHOS in CNS energy supply, most mitochondrial diseases manifest as alterations in CNS function and neuronal damage.
- Assessing the Extent of Central Nervous System Involvement
Neuroimaging enables a comprehensive evaluation of the structure and function of the central nervous system to determine the degree to which mitochondrial diseases impact the brain and spinal cord.
- Detection of Brain Structural and Anatomical Abnormalities
Brain structural and anatomical irregularities associated with mitochondrial dysfunction can be detected using neuroimaging modalities, which aid in pinpointing the location of the lesion.
- Studying Mitochondrial Dysfunction
Moreover, neuroimaging may be used to study the function of a mitochondrion at a central nervous system level, involving energy metabolism and oxidative phosphorylation, thus shedding light on the scope of mitochondrial dysfunction.
- Monitoring Disease Progression
Neuroimaging examinations can constantly monitor and bring about any structural and functional changes well ahead of time to suffice as an alert or early marker, so slowed pace of progress for advancement of the disease.
- Identifying Brain Regions Associated with Symptoms
Neuroimaging provides identification of the areas how through which diseases of mitochondrial manifest, such as impaired cognitive function and disorders of motor activity, which assists in formulating directed and more efficient therapy interventions.
Our Services
It is essential for the management of mitochondrial diseases that neurological involvement is detected at early stages. Early diagnosis of structural and functional changes relevant to mitochondrion diseases is aided by Protheragen's neuroimaging service, which is a crucial foundation for diagnosing mitochondrial diseases.
Advanced Imaging Modalities
- Magnetic resonance imaging (MRI)
- Positron emission tomography (PET)
These advanced techniques facilitate precise visualization of neurological abnormalities associated with mitochondrial diseases.
Functional Imaging
We deliver functional imaging studies for assessing cerebral blood flow, metabolism, and connectivity, which allows for a thorough interpretation of how mitochondrial dysfunction affects the physiology of the brain. It helps in the recognition of certain features that suggest mitochondrial disorders.
Magnetic Resonance Spectroscopy
Using a three-dimensional voxel of specific dimensions, magnetic resonance spectroscopy (MRS) can be utilized to identify the chemical composition of certain brain regions. At the same time, it is also a powerful device for those who seek to detect neurochemical abnormalities in diseased populations.Quantitative Analysis
Quantitative Analysis
Our team employs advanced quantitative analysis techniques to derive important information from neuroimaging studies, which enables us to analyze the effects of mitochondrial diseases on the nervous system.
Multi-Modal Integration
The amalgamation of data from various imaging modalities allows for an understanding of the neurological features of mitochondrial diseases to be more comprehensive. Such an approach helps in achieving high diagnostic accuracy.
Our Advantages
The specialized mitochondrial disease neuroimaging service of our company exists to meet the unique needs of researchers working in the leading edge of mitochondrial disease. If you have any inquiries regarding how our detailed neuroimaging services can facilitate your goals, do not hesitate to contact us.
