Mitochondrial metabolism is arguably the most intricate aspect of cellular metabolism.
The dual genetic regulation governing oxidative phosphorylation (OXPHOS), whereby
proteins are encoded by either nuclear or mitochondrial genomes (mitochondria being the
sole organelles subject to such dual genetic control), The mission of Our company is to provide cutting-edge solutions for the identification and
development of protein biomarkers associated with mitochondrial diseases.
Common Protein Biomarkers for Mitochondrial Diseases
The identification of protein biomarkers associated with mitochondrial diseases can
offer invaluable insights to facilitate the progress of diagnostic development.
Myoglobin
In certain mitochondrial disorders, elevated levels of myoglobin may indicate
muscle damage or abnormal mitochondrial function.
Mitochondrial DNA (mtDNA) and Associated Proteins
Detection of alterations in mitochondrial DNA and the proteins linked to it can
unveil indications of mitochondrial genetic diseases.
The Neurofilament Light Chain
The neuron-specific protein serves as a valuable indicator for monitoring the
progression of neuronal damage in MDs.
Mitochondrial Permeability Transition Pore Proteins
The proteins are crucial for maintaining the integrity of the mitochondrial
membrane, and their abnormalities may be linked to mitochondrial disorders.
Gelsolin
The cytoskeletal protein has been proposed as a potential therapeutic target for
OXPHOS dysfunction due to the well-established interaction and movement of
mitochondria along microtubules and actin filaments.
Our Services
Mitochondrial diseases encompass a range of conditions that impact the functionality of
mitochondria within the human body, which are responsible for cellular energy production.
The compromised ability of mitochondria to generate sufficient energy required by the body
directly influences the proper functioning of vital organs. Our company provides tailored protein biomarker development services for
mitochondrial diseases, catering to our client's specific requirements.
Sample Collection and Processing
Assist clients in determining appropriate sample types, such as blood or tissue.
Provide standardized procedures for sample handling to ensure optimal protein
extraction and preservation.
Protein Analysis and Identification
Utilize advanced protein analysis techniques, such as mass spectrometry and
proteomics, to identify specific protein biomarkers associated with mitochondrial
disease, ensuring enhanced accuracy and specificity.
Bioinformatics Analysis
Conduct bioinformatics analysis, including pathway analysis and functional
annotation, to gain in-depth insights into the biological significance of markers.
Provide customers with comprehensive data interpretation and analysis reports.
Validation and Verification Experiments
To ensure the reliability of the markers, further validation through experimentation
and other methods is necessary. Assistance will be provided in designing validation
experiments to facilitate successful confirmation of our findings in laboratory
settings.
Reporting and Delivery
Furnish comprehensive reports encompassing experimental design, analytical
methodologies, interpretation of findings, and other pertinent details. Provide
clients with data, samples, and associated documentation for extensive utilization
in their research endeavors.
Our Advantages
Reliable Data and Results
Protheragen is dedicated to providing customers with top-notch,
specialized services that advance scientific research in the field of mitochondrial
diseases. If you are interested in our services, please do not hesitate to contact us for more detailed information.
