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Protein Biomarkers Development Service

Protein Biomarkers Development Service

Arguably, the cellular metabolism complex is mitochondrial metabolism. For example, the oxidative phosphorylation (OXPHOS) process is unique in that it is a dual genetic regulation whereby proteins are encoded by either nuclear or mitochondrial genomes. The mitochondria are the only organelles that fall under the control of dual genetics. Protheragen specializes in the identification and development of protein biomarkers that are associated with mitochondrial diseases.

Common Protein Biomarkers for Mitochondrial Diseases

The development of diagnostics can greatly benefit from protein biomarkers for mitochondrial-associated disorders.

Myoglobin

In certain disorders, myoglobin might be increased in concentration as a marker for muscle injury or abnormal working mitochondria.

Mitochondrial DNA (mtDNA) and Associated Proteins

Some defects in the mitochondria DNA and the corresponding proteins may show features of the mitochondrial genetic disorder.

The Neurofilament Light Chain

The neuron-specific protein is one of the promising biomarkers for the assessment of the extent of neuronal injury in MDs.

Mitochondrial Permeability Transition Pore Proteins

The proteins are important in preserving the structure of the mitochondria and their abnormal expression can predispose to mitochondrial diseases.

Gelsolin

This cytoskeleton protein is a potential drug target for OXPHOS dysfunctions due to the known association of mitochondria movements with the microtubule and actin filament.

Our Services

Mitochondrial disorders are a group of diseases affecting the energy-generating structures within human cells. The diminished capacity of mitochondria to produce adequate energy, necessary for the sustention of life, directly affects the proper functioning of critical organs. Our company specializes in custom development services of protein biomarkers for mitochondrial disorders using a client-centric approach.

Sample Collection and Processing

Sample Collection and Processing

Assist customers in determining appropriate samples such as blood/tissue. Provide guidelines on sample management to maximize protein recovery and retention.

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Protein Analysis and Identification

Protein Analysis and Identification

Adopt mass spectrometry and proteomics analysis techniques to identify biomarkers for mitochondrial disease proteins in order to achieve greater precision and accuracy.

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Bioinformatics Analysis

Bioinformatics Analysis

Perform bioinformatics analysis that includes marker biological significance pathway analysis and functional annotation. Provide customers with in-depth data interpretation and analysis reports.

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Validation and Verification Experiments

Validation and Verification Experiments

More experimentation and other techniques are required to confirm the reliability of the markers, and effort will be made to aid the design of the experiments needed for validation within the laboratory.

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Reporting and Delivery

Provide the complete report from the initial stages to the last details such as the scope of work, experimental approaches, findings, and other relevant factors. Supply clients with data, samples, and supporting material.


Our Advantages

Professional Team

Professional Team

Advanced Technology Platform

Advanced Technology

Comprehensive Range Services

Comprehensive Services

Reliable Data and Results

Reliable Data and Results

Protheragen focuses on delivering exceptional and unique services that foster scientific advancement in the area of mitochondrial diseases. For any additional questions regarding our specialized services, please feel free to contact us

For research use only, not for clinical use.