Mitochondrial diseases are a prevalent and serious set of genetic disorders that are passed down through families, and they show a great variety in their presentation, biochemistry, and genetic features. Particularly in the absence of effective individualized disease-modifying or curative therapies, the journey toward a diagnosis can be quite complex. With deep knowledge of the detailed pathophysiology of these disorders, Protheragen offers extensive assistance in the design, development, and optimization of therapeutic antibodies targeted toward the dysfunction of mitochondria.
Our Services
Protheragen works closely with academic researchers, biotechnology firms, and pharmaceutical companies to accelerate the development of novel therapies for mitochondrial disorders. A multidisciplinary team with deep expertise in molecular biology, immunology, protein engineering, and preclinical evaluation integrates all steps in antibody development and offers bespoke assistance at every stage.
Target
Discovery
Using the multidisciplinary approaches brought by genetics, biochemistry, and disease pathology we assist in the identification and validation of molecular targets associated with mitochondrial dysfunction where promising antibody targets are prioritized.
Antibody
Generation
Using hybridoma-based methods, phage display libraries, and B-cell screening with advanced antibody discovery platforms, we create monoclonal antibodies that are highly specific and have very high affinity to mitochondrial antigens.
Antibody
Optimization
Employing modern techniques of protein engineering, the antibodies are modified to improve their properties such as affinity, specificity, stability, immunogenicity, and other parameters to augment their therapeutic efficacy and reduce unwanted side effects.
Antibody
Validation
Preclinical studies we offer include in vivo and in vitro studies with disease models such as animal or cellular models of mitochondrial diseases for the evaluation of the antibody candidate’s therapeutic effectiveness, safety, and pharmacokinetics.
Our Advantages
- Customized Solutions
Development and customized tuning of these antibody-based therapies for clients is not only efficient but also flexible to meet the desired goals and needs of each client.
- Scientific Expertise
Our expert scientists and immunologists with their extensive specialization in mitochondrial biology and antibody engineering guarantee the successful development of therapeutic strategies.
- Rapid Development Timeline
By optimizing the process of developing antibodies, the duration of projects can be shortened greatly, which increases the speed at which scientific discoveries can be converted into therapeutic options.
- Regulatory Compliance
Through stringent quality and regulatory controls, the safety and efficacy of antibody-based therapies are guaranteed, thereby facilitating a seamless transition to commercial development.
The antibody development service for therapy provided by Protheragen allows for a multifaceted and integrated approach toward advanced therapy of mitochondrial diseases. Our experts would be happy to discuss further details on our collaborative opportunities for developing therapeutic antibodies against mitochondrial diseases, please do not hesitate to contact us.
