Model Development Services for Rare Childhood Diseases
In the field of rare pediatric disease research, high-quality disease models are critical tools to advance drug discovery and development. To support your research needs, Protheragen offers a comprehensive range of disease model development services, including in vivo and in vitro models, to help you explore rare pediatric diseases more efficiently and accelerate the drug discovery process.
Animal Models of Rare Childhood Disease
Animal models play an important role in rare disease research, especially in the exploration of disease mechanisms, drug screening and safety assessment. Commonly used animal models include mice, rats, and zebrafish.
Figure 1. WAG/RijY rats with clinical signs of bleeding. (Booth CJ, et al., 2010)Cellular Models of Rare Childhood Diseases
Cellular models are equally important in rare disease research, especially in the study of disease mechanisms and drug development.
Figure 2. Adipose Mesenchymal Stem Cells (Ad-MSC) are used for hemophilia A studies. (Barbon S, et al., 2022)Gene Editing Technology for Rare Childhood Disease Research
Gene editing technology provides new tools for rare disease research. By pinpointing and correcting gene mutations, researchers can mimic the pathological features of rare diseases in animal and cellular models and explore potential treatments.
Our Services
Animal Model Development Services for Rare Childhood Diseases
We provide you with ideal animal models of diseases in rare children through new technologies such as gene editing technology, genome-wide humanized models, and multidisciplinary integration. The models will provide a more solid foundation for in-depth understanding of disease mechanisms, discovery of drug targets and evaluation of therapeutic effects.
Optional animal model types:
- Genetically engineered models
- Non-genetically engineered models
- Homologous models
- Xenograft models
- Humanized animal models
Optional species:
- Mouse model
- Rat model
- Zebrafish model
- Monkey, pig and other animal models
In Vitro Model Development Services for Rare Childhood Diseases
We are committed to providing you with professional in vitro modeling services to help you make breakthroughs in your research. Whether you are exploring disease mechanisms, developing novel therapeutics, or conducting drug screening, we can customize the right in vitro model for you.
Optional cell model types:
- Cell line development
- Primary cell development
- iPSC development
Optional organoid model types:
- Adult stem cell (ASC)-derived organoids
- Embryonic stem cell (ESC)-derived organoids
- Patient-derived organoid (POD)
Why Choose Us?
- Diversified model development solutions from in vivo to in vitro
- Rich experience in model development and deep technical accumulation
- Customized support
- Strict quality control system
- Ensure the reliability and reproducibility of models
- Efficient project management to shorten the development cycle
Drug Discovery Services for Rare Childhood Diseases
If you are developing drugs for rare pediatric diseases, we can also help you screen potential drugs through in vitro cellular models, and then verify their safety and efficacy through in vivo animal models.
We believe that through our disease model development services, you will be able to gain a deeper understanding of rare pediatric pathologies and accelerate the drug screening and development process. If you are interested in our services or would like to learn more about how we can customize a model for your project, please feel free to contact us.
References
- Booth CJ, Brooks MB, Rockwell S. Spontaneous coagulopathy in inbred WAG/RijYcb rats. Comp Med. 2010;60(1):25-30.
- Barbon S, Stocco E, Rajendran S, et al. In Vitro Conditioning of Adipose-Derived Mesenchymal Stem Cells by the Endothelial Microenvironment: Modeling Cell Responsiveness towards Non-Genetic Correction of Haemophilia A. Int J Mol Sci. 2022;23(13):7282.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.