Research and development into rare ophthalmological diseases is often limited, making the development of appropriate drugs and therapies challenging. Our company is dedicated to addressing this gap by providing comprehensive drug and therapy development services for rare ophthalmological diseases.
Ophthalmic diseases encompass a wide range of conditions that affect the eyes and visual system. These diseases can be categorized into various subtypes, including but not limited to, ocular surface disorders, corneal diseases, retinal disorders, glaucoma, uveitis, and genetic eye diseases. Ophthalmological diseases can lead to visual impairment or blindness if left untreated, making their diagnosis and therapy of utmost importance.
Fig.1 Schemes of the eye structure, common ocular diseases, and ocular drug administration routes. (Nhàn N T T, et al., 2023)These therapies involve the transplantation of healthy cells or stem cells to replace damaged or degenerated cells in the retina or cornea. Stem cell-based therapies hold immense potential for regenerating damaged retinal cells and restoring vision in diseases like retinitis pigmentosa and Stargardt disease.
Many rare ophthalmological diseases are caused by specific genetic mutations. Gene therapies aim to correct these mutations or provide functional copies of the defective genes to restore vision. This approach has shown success for certain rare genetic eye diseases and holds great potential.
Drug Therapies
This includes the development of small molecules, biologics, and gene therapies that target specific molecular pathways involved in the disease progression. These therapies can be administered topically, orally, or through intravitreal injections, depending on the disease and its location.
Neovascularization and Angiogenesis
Conditions like age-related macular degeneration (AMD) and diabetic retinopathy are characterized by abnormal blood vessel growth in the retina. Therapies targeting angiogenesis pathways aim to inhibit the growth of these vessels and preserve visual function.
The development of therapies for ophthalmological diseases involves targeting specific molecular pathways and cellular mechanisms involved in the disease progression. Our company is at the forefront of ophthalmological disease diagnostics and therapeutics development. We offer a wide range of services to aid in the development of novel therapies for ophthalmological diseases.
We understand the importance of reliable animal models in eye disease research. Our experts have successfully developed and characterized a variety of animal models that mimic human eye diseases. Our comprehensive preclinical testing services include rigorous in vitro and in vivo evaluation of potential therapeutics. We utilize state-of-the-art technologies and methods to evaluate the efficacy, safety, and pharmacokinetics of drug candidates.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
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