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Project Description

Please note that we are a research service provider, not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Ciliary Body Cyst

Ciliary body cysts are rare, benign lesions that arise within the pigmented epithelial layer of the iris and ciliary body. By leveraging our extensive expertise and cutting-edge technologies, Protheragen provides end-to-end solutions from diagnostics to therapy development.

Overview of Ciliary Body Cyst

Fluid-filled cavities known as ciliary body cysts arise from the pigmented epithelial layer of the ciliary body, a part of the eye that produces the aqueous humor and controls intraocular pressure. These cysts can be classified as primary or secondary. Primary ciliary body cysts are congenital and occur without any external influence, whereas secondary cysts can develop from trauma, inflammation, or other diseases. Though most ciliary body cysts are harmless, they are sometimes responsible for complications such as angle-closure glaucoma, especially when they are associated with an angle of more than 180 degrees.

Fig.1 Screening protocol for ciliary body cysts (CBCs). (Coc I. R., et al., 2024)

Diagnostic Method of Ciliary Body Cyst

Ultrasound Biomicroscopy (UBM)
Ultrasound biomicroscopy (UBM) is the preferred method to identify ciliary body cysts. With UBM, a high-frequency ultrasound transducer is used to produce the highest quality detail images of the anterior part of the eye. This allows for clear identification and assessment of the size of the cysts. UBM is also able to differentiate primary cysts of the iris pigment epithelium from solid uveal neoplasia, thereby aiding in the identification of benign cysts in comparison to more severe pathological conditions.

Optical Coherence Tomography (OCT)
In assessing the ciliary body cysts, optical coherence tomography (OCT) functions as another imaging technique. With OCT, the anterior segment of the eye can be imaged into exquisite cross-section using lightwaves. Although OCT is inferior to UBM in cyst identification owing to its shallow depth of penetration, it supplies important informing understanding concerning the iris and ciliary body region.

Therapeutics Development for Ciliary Body Cyst

For ciliary body cysts, therapeutic primarily aims at is managing intraocular pressure with the help of topical and systemic medications. Pilocarpine as a parasympathomimetic agent is usually helpful in IOP lowering due to pupil miosis and opening of the iridotrabecular angle. Other medications may also be given such as timolol or brimonidine for better controlling IOP. In some instances, oral acetazolamide may be given to reduce the production of aqueous humor.

Our Services

Protheragen endeavors to deliver customized services tailored towards the specific requirements of our customers. Our specialists collaborate with researchers and industry stakeholders to design and execute custom diagnostic and therapeutic solutions for cysts of the ciliary body.

Diagnostics Development

Karyotype Analysis Service
Omics Analysis Service
Biomarker Development Service
Artificial Intelligence Service

Therapeutic Development

Small Molecule Drug
Cell Therapy
Gene Therapy
Therapeutic Antibody
Therapeutic Peptide
Therapeutic Protein
Customized Therapy Development

Disease Models

Retinal Degeneration Models
Glaucoma Models
Cataract Models
Corneal Wound Healing Models
Uveitis Models

Preclinical Research

Pharmacodynamics Study Services
Pharmacokinetics Study Services
Drug Safety Evaluation Services
Customized Research Services

Protheragen's preclinical research services focus on advancing the understanding of ciliary body cysts through rigorous scientific investigation. Our preclinical studies utilize animal models to study the pathophysiology of ciliary body cysts and to test the efficacy and safety of novel therapeutic agents. If you are interested in our services, please feel free to contact us.

References

Coc, Ivana Romac, et al. "Evaluation of ciliary body cysts in candidates for phakic lens implantation." International Ophthalmology 44.1 (2024): 402.
Schmalfuss, Tiago Ribeiro, Egidio Picetti, and Helena Messinger Pakter. "Glaucoma due to ciliary body cysts and pseudoplateau iris: a systematic review of the literature." Arquivos Brasileiros de Oftalmologia 81 (2018): 254-261.