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Project Description

Please note that we are a research service provider, not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Epibulbar Dermoid

A focused broad approach which includes top-notch genetic screening and novel therapeutics development is required to formulate successful strategies for the diagnostics and therapeutics of epibulbar dermoids. Protheragen leads this pioneer's charge, delivering unparalleled therapeutic development services.

Overview of Epibulbar Dermoid

Epibulbar dermoids are developmental cysts located on the conjunctival portion of the sclera which is a form of ocular dermoids. They represent a relatively common ocular surface abnormality that may be unilateral or bilateral and of variable size ranging from small to large. Epibulbar dermoids sometimes accompany more complex syndromes like Goldenhar syndrome which is characterized by other anomalies such as preauricular tags, facial asymmetry, and other craniofacial deformities.

Prediction of the three-dimensional structure of PTCH1 protein.

Fig.1 The 3D structure of the PTCH1 protein predicted using the SWISS-MODEL. (Naveed M., et al., 2024)

Combined factors such as genetic mutation and abortion of embryonic processes are the impetus for epibulbar dermoid disease. Important to note is the mutation within the Patched 1 (PTCH1) gene which is responsible for the receptor protein of the Hedgehog signaling path. Embryonic development of tissue necessitates the coordination of a multitude of events and this specific pathway is one such integral event.

Diagnostics Development for Epibulbar Dermoid

Genetic Testing

Research is now increasingly concentrating on pathogenic alterations associated with the PTCH1 gene as part of genetic study of epibulbar dermoid. The mutations serve to explain the diagnosis as well as to illuminate some of the genetic construction of the condition.

Histopathological Examination

The diagnosis of epibulbar dermoid is definitive through histopathological examination of the biopsy specimens. Analysis under the microscope displays the presence of skin components amongst other features. This method is very effective in complicated cases that are difficult to interpret.

Therapeutics Development for Epibulbar Dermoid

Artificial Intelligence (AI)-Assisted Drug Design
The innovation brought forward in AI is invaluable to the design of drugs for epibulbar dermoid. New therapeutic compounds targeting the PTCH1 protein have been developed from natural molecules like Fisetin using AI platforms like WADDAICA. These compounds are highly potent, low in toxicity, and have a latitude of promise as non-invasive therapeutics.
Phytochemicals
Fisetin and a range of phytochemicals have been studied for their possible therapeutics of epibulbar dermoid. These compounds possess anti-inflammation, anti-oxidation, and anti-proliferation activities which can help mitigate cell signaling pathways associated with the formation of dermoid cysts. Fisetin, which occurs in Neolamarckia cadamba and other plants, has shown an ability to interfere with the Hedgehog signaling pathway which seems to curb the growth of dermoid cells.

Our Services

Protheragen provides a complete service package focused on diagnostics and therapeutic development for epibulbar dermoid. We cover the entire process of genetic consulting, histopathological study, and the development and verification of new therapeutic agents with the use of AI and phytochemicals.

Diagnostics Development

Karyotype Analysis Service
Omics Analysis Service
Biomarker Development Service
Artificial Intelligence Service

Therapeutic Development

Small Molecule Drug
Cell Therapy
Gene Therapy
Therapeutic Antibody
Therapeutic Peptide
Therapeutic Protein

Preclinical Research

Pharmacodynamics Study Services
Pharmacokinetics Study Services
Drug Safety Evaluation Services

Disease Models

Spontaneous Epibulbar Dermoid Canine Models
PTCH1 Mutation Rodent Models
Dermoid Tissue Implantation Rabbit Models
Genetic Engineering Non-Human Primate Models

Protheragen conducts rigorous preclinical testing of novel therapies, including gene and stem cell therapies, using animal models of epibulbar dermoid. If you are interested in our services, please feel free to contact us.

References

Naveed, Muhammad, et al. "Comparative toxicity assessment of fisetin-aided artificial intelligence-assisted drug design targeting epibulbar dermoid through phytochemicals." Open Chemistry 22.1 (2024): 20230197.
Choudhary, Dharamveer Singh, et al. "Massive corneal-epibulbar dermoid managed with pre-descemetic DALK and SLET." GMS Ophthalmology Cases 11 (2021).
Kaouani, Amine, et al. "Management of a giant ocular epibulbar dermoid." Journal of Pediatric Surgery Case Reports 71 (2021): 101944.