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Though iris cysts are not very common, they create major problems with the diagnosis and therapy of various ophthalmic conditions. At Protheragen, we offer comprehensive Iris Cyst therapy development services that encompass the entire spectrum of diagnostic and therapeutic approaches.
An iris cyst refers to an intraocular fluid-filled lesion that occurs in the iris or the colored part of one's eye. These cysts can be classified based on their origin and etiology. Primary iris cysts are developmental or congenital in nature, frequently arising from the iris pigment epithelium (IPE) or iris stroma. Secondary iris cysts, in contrast, result from extrinsic factors like trauma, surgery, or inflammation. Depending on their size, location, and growth pattern, iris cysts may be asymptomatic or cause significant visual disturbances.
Fig.1 Histopathology image of iris cyst. (Dubey S., et al., 2021)
Primary Iris Cysts
Stromal Cysts
These cysts may be either congenital or acquired. The existing theories regarding the cause of congenital stromal cysts suggest that they result from the trapping of surface ectoderm in the process of lens vesicle formation. Acquired stromal cysts cysts may arise from trauma or other types of external influence.
Iris Pigment Epithelial (IPE) Cysts
These cysts are believed to arise from developmental abnormalities which stem from the widening of the potential space within the layers of the iris pigment epithelium. They are usually congenital and can stay inactive for many years before they turn out to be evident.
Secondary Iris Cysts
Epithelial Implantation Cysts
These cysts develop when epithelial cells from the eyelid, conjunctiva or cornea penetrate into the anterior chamber via a wound (surgical or traumatic) and multiply on the surface of the iris.
Drug-Induced Cysts
Taking certain medications, especially prostaglandin analogs or miotics for an extended period can result in developing cysts at the border of the pupil.
Parasitic Cysts
Cysts may sometimes develop from intraocular parasitic infection, for instance—cysticercosis.
| Therapeutics | Target | Description | Research Stage |
| Mitomycin C | Epithelial Downgrowth Cysts | Used in conjunction with aspiration to prevent the recurrence of epithelial cysts. | Approved |
| 5-Fluorouracil (5-FU) | Epithelial Downgrowth Cysts | Injected into cysts to inhibit cell proliferation and prevent recurrence. | Approved |
| Prostaglandin Analogs | Drug-Induced Cysts | Discontinuation of prostaglandin analogs to resolve drug-induced cysts. | Approved |
| Anti-Parasitic Drugs | Parasitic Cysts | Used in cases of parasitic cysts, such as those caused by cysticercosis. | Approved |
Disclaimer: Protheragen focuses on providing preclinical research services. This table is for information exchange purposes only. This table is not a treatment plan recommendation. For guidance on treatment options, please visit a regular hospital.
Recognizing the unique needs of each patient and research project, Protheragen offers customized services tailored to specific requirements. Our team collaborates closely with researchers to design customized diagnostic and therapeutic development services.
Protheragen's preclinical research services play a pivotal role in advancing the understanding and therapeutics of iris cysts. Our state-of-the-art facilities and expert team conduct rigorous preclinical studies to evaluate the efficacy and safety of novel diagnostic and therapeutic approaches. If you are interested in our services, please feel free to contact us.
References
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