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Project Description

Please note that we are a research service provider, not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Metastatic Orbital Tumors

Metastatic orbital tumors are uncommon, comprising 1-13% of all orbital tumors, and are almost always linked with systemic cancers. Protheragen provides extensive support services for the design and development of diagnostic and therapeutic for metastatic orbital tumors.

Introduction to Metastatic Orbital Tumors

Tumors that metastasize to the orbits are a significant clinical problem in oncology because these tumors, which arise in the orbit—the bony cavity that encases the eye, spread from a primary tumor located elsewhere. They are not common, but their proximity to vital parts of the eye makes them very morbid. The frequency of cases of metastatic orbital tumors has grown in the past few years due to better survival rates among patients suffering from common malignancies including breast, prostate, and lung cancers, as well as better imaging and biopsy surgical techniques. Metastatic orbital tumors most often arise from breast carcinoma, melanoma, prostate and lung carcinoma.

A case of histopathological analysis of a metastatic orbital tumor.

Fig.1 Histopathological analysis of metastatic orbital tumors. (Ito H., et al., 2022)

Diagnostics Development for Metastatic Orbital Tumors

Histopathological Analysis
Fine-needle aspiration biopsy (FNAB) and incisional biopsy are vital methods for the procurement of tissue specimens for histology examination to confirm diagnosis. The employment of next-generation sequencing (NGS) alongside immunohistochemistry enables the detection of relevant genetic alterations and the associated cancer biomarkers of interest. For instance, the expression of estrogen receptors in breast cancer metastatic lesions can influence the decision concerning the use of hormonal therapy.
Molecular and Genetic Testing
The management of metastatic orbital tumors has incorporated molecular diagnostics to a greater extent than before. CTCs and cfDNA can be detected in blood through liquid biopsy methods that enable non-invasive monitoring and early detection of metastatic disease. Such methods can help in real-time assessment of the tumor burden as well as the therapy's efficacy, enabling the development of individualized therapeutics plans.

Therapeutics Development for Metastatic Orbital Tumors

Chemotherapy is systemically administered for chemosensitive tumors like small cell lung cancer and neuroblastoma. There has been improvement in the results of targeted therapies such as hormone therapy for breast or prostate cancer. For instance, inhibiting estrogen secretion using aromatase inhibitors in metastatic breast cancer is effective. Immunotherapy has been effective in the therapeutic of metastatic melanoma using checkpoint inhibitors, where patients achieved durable responses.

Our Services

Specialized knowledge that we possess incorporates sophisticated histopathology research and molecular pathology which serves for proper and early locating of metastatic lesions. Our highly qualified scientific personnel and modern equipped laboratories guarantee customers receive the highest quality tailored diagnostics and therapeutics development solutions.

Diagnostics Development

Karyotype Analysis Service
Omics Analysis Service
Biomarker Development Service
Artificial Intelligence Service
Customized Diagnostics Development

Therapeutic Development

Small Molecule Drug
Cell Therapy
Gene Therapy
Therapeutic Antibody
Therapeutic Peptide
Therapeutic Protein
Customized Therapy Development

Disease Models

Orthotopic Implantation Models
Retro-Orbital Inoculation Models
Patient-Derived Xenograft (PDX) Models
Microsurgical Induced Cancer Models

The preclinical research services provided by Protheragen are intended for the rapid advancement of new therapeutic options for orbital metastatic tumors. We also offer an extensive selection of services which includes in vitro and in vivo studies, PK/PD analysis, and toxicology assessments. If you are interested in our services, please feel free to contact us.

References

Ito, Hiroaki, et al. "Histopathological and immunohistochemical findings of metastatic orbital tumors: a series of 7 cases." Human Pathology Reports 28 (2022): 300609.
Palmisciano, Paolo, et al. "Orbital metastases: a systematic review of clinical characteristics, management strategies, and treatment outcomes." Cancers 14.1 (2021): 94.