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Project Description

Please note that we are a research service provider, not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Neuroretinitis (NR)

Neuroretinitis refers to a disease affecting the eye which encompasses inflammation of the optic nerve and the surrounding retina. Protheragen is able to provide a complete scope of services for diagnostics and therapeutics development for Neuroretinitis due to the industry's most advanced platform and an exceptional technical team.

Introduction to Neuroretinitis (NR)

Vision loss along with retinitis inflammation and optic disc swelling with macular star exudates is called neuroretinitis (NR). NR is usually linked with severe vision impairment and can be unilateral or bilateral. The condition can occur with or without a known cause, or associated with infectious and autoimmune pathogens, such as cat scratch disease (CSD) caused by Bartonella henselae and viral infections. Vision impairment occuring with swelling of the optic disc and macular exudate in a star shaped pattern is what Neuroretinitis is.

Macular Optical Coherent Tomography (OCT) showed the presence of intraretinal and subretinal fluid.

Fig.1 Macular optical coherence tomography (OCT) analysis in neuroretinitis. (Paz, T., et al., 2017)

Diagnostic Methods for Neuroretinitis (NR)

In the context of neuroretinitis, molecular diagnostics are important for therapeutic development. With the advancement of molecular techniques, specific pathogens related to NR, such as Bartonella henselae in certain cases of CSD, have been detected.

PCR-Based Detection: PCR assays targeting the 16S rRNA gene of Bartonella henselae have been used to confirm the pathogen in cases with suspected CSD-associated NR. This molecular technique is very effective because it has a high sensitivity and specificity which makes it useful for accurate and fast diagnosis.

Next-Generation Sequencing (NGS): NGS methods have been used for sequencing the genomes of the pathogens and provided valuable information on the existing variations and the possibility of drug resistance. This integrative method helps to clarify the pathogenesis and formulate precise therapeutics.

Therapeutics Development for Neuroretinitis (NR)

Antibiotic Therapy

In the context of Bartonella henselae-related non-arteritic ischemic optic neuropathy (NAION), therapeutic with doxycycline has proven effective in resolving optic disc swelling alongside improvement in visual acuity.

Corticosteroid Therapeutics

For NR of unidentified origin, systemic corticosteroids are commonly administered to reduce inflammation and aid recovery.

Immunosuppressive Agents

For frequent or stubborn cases, immunosuppressive agents might be considered. Such agents include but are not limited to azathioprine or mycophenolate mofetil as these agents facilitate modulation of immune response to reduce inflammation from recurrent cases.

Our Services

Protheragen provides a full range of services including Neuroretinitis diagnostic procedures and therapeutics development. Our modern facilities, coupled with our specialized knowledge in molecular biology, immunology, and pharmacology, put us at the forefront of NR therapeutics development.

Diagnostics Development

Karyotype Analysis Service
Omics Analysis Service
Biomarker Development Service
Artificial Intelligence Service
Customized Diagnostics Development

Therapeutic Development

Small Molecule Drug
Cell Therapy
Gene Therapy
Therapeutic Antibody
Therapeutic Peptide
Therapeutic Protein
Customized Therapy Development

Preclinical Research

Pharmacodynamics Study Services
Pharmacokinetics Study Services
Drug Safety Evaluation Services

Disease Models of Neuroretinitis (NR)

In Vitro Models: We perform cell cultures to test the activity of antibiotics and the inflammation-mediated actions of corticosteroids and immunosuppressive drugs.

In Vivo Models: We have developed and optimized certain in vivo models so that relevant biological interventions can be performed and the impact can be assessed. We employ animal models of NR to examine its natural history and the effects of different therapeutics on the visual and retinal structure-function relationships.

Cat Scratch Disease (CSD) - Induced Neuroretinitis Models
Idiopathic Neuroretinitis Models

Viral-Induced Neuroretinitis Models
Chemical-Induced Neuroretinitis Models

Protheragen's preclinical research services offer a robust platform for evaluating new HSK diagnostics and therapeutics. Our state-of-the-art facilities and expert scientific team conduct comprehensive studies to assess the efficacy, safety, and pharmacokinetics of novel agents. If you are interested in our services, please feel free to contact us.

Reference

Paz, T., et al. "Treating Macular Edema with Nepafenac in Neuroretinitis."