Tourette Syndrome Research Services
Tourette Syndrome is a complex neurodevelopmental disorder, the cause of which is not fully understood. The current pain points in Tourette's research cover a wide range of causes, diagnoses and treatments. Our company offers a wide range of customized services to researchers working on Tourette's. We are committed to helping researchers delve deeper into the causes of disease, standardize diagnostic tools and develop personalized treatment options. Our multidisciplinary approach can help you better meet the challenges of Tourette's complex disease.
What Is Tourette Syndrome?
Tourette Syndrome (TS), is a neurodevelopmental disorder characterized by involuntary repetitive movements and vocal tics. The disorder usually begins in childhood and symptoms may persist into adulthood, but its severity varies with age.
Figure 1. Models of Tourette syndrome pathophysiology. (Johnson KA, et al., 2023)Etiology and Genetic Factors of Tourette Syndrome
Tourette Syndrome is a complex neurodevelopmental disorder whose etiology involves a number of factors including genetics, environment and neurotransmitters. Studies have shown that genetic variants, such as genes associated with dopamine receptors (e.g., DRD2, DRD4) and genes associated with DNA methylation (e.g., NR3C1), are present in people with Tourette's. In addition, family studies have shown a genetic predisposition to Tourette's, with relatives at higher risk for the disease.
Treatment of Tourette Syndrome
- Behavioral therapy
- Medication
- Deep Brain Stimulation (DBS)
Our Services
Analysis of Neurological Mechanisms in Tourette Syndrome
- Neurotransmitter analysis, such as dopamine and serotonin
- Neural network analysis, e.g. activation of anterior cingulate gyrus, prefrontal cortex and hypothalamic regions
- Analysis of gene variants and genetics, e.g. DRD2, HTR2A, etc.
- Neuroimaging analyses, e.g., functional analyses of regions of the basal nuclei, pallidum, thalamus, and prefrontal cortex
The neural mechanisms of Tourette Syndrome are complex and varied, involving the interaction of neurotransmitters, neural networks, genetic variants, and environmental factors. We are committed to helping researchers further explore the specific connections between these mechanisms and develop more effective therapies.
Model Development Services for Tourette Syndrome
In vivo models:
- Histidine decarboxylase knockout mice
- D1CT-7 mouse model
- Celsr3 and WWC1 mutant mice
- SD rat model established by intraperitoneal injection of iminodinone acetonitrile (IDPN)
Choosing our animal model of Tourette's as an important tool in your study of its pathomechanisms and exploration of therapeutic strategies will accelerate your research.
In vitro models:
- iPSC-derived three-dimensional brain organoid models
Our Technical Approach:
- Generation and Differentiation of iPSC
- Three-dimensional organoid culture
- Gene editing and drug screening
Our iPSC-derived three-dimensional brain organoid models can better reproduce the anatomical and functional characteristics of the human brain. Combined with single-cell sequencing technology and artificial intelligence algorithms, we can help you better analyze the molecular mechanisms and pathogenesis of Tourette's disease.
Genetics Research Services for Tourette Syndrome
- Genome-Wide Association Studies (GWAS)
- Genome Sequencing and Variant Analysis
- Linkage Analysis & Complex Segregation Analysis
- Neuroimaging & Biomarker Studies
Our approaches to the genetics of Tourette syndrome range from genome sequencing to neuroimaging. These approaches will not only help researchers to unravel the genetic basis of Tourette's, but also provide important clues for the development of targeted therapeutic strategies in the future.
Reference
- Johnson KA, Worbe Y, Foote KD, Butson CR, Gunduz A, Okun MS. Tourette syndrome: clinical features, pathophysiology, and treatment. Lancet Neurol. 2023;22(2):147-158.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.