Asphyxia Neonatorum
Asphyxia neonatorum is a disease caused by insufficient oxygen supply to newborns before, during, or before birth. Our company is committed to driving forward the field of asphyxia neonatorum research. With our exceptional team of accomplished researchers and scientists, we are at the forefront of pioneering advancements in the development of diagnostic tools and therapeutic drugs to effectively manage this complex disease. As your trusted partner in asphyxia neonatorum research, we provide seamless and all-encompassing support to meet your scientific research needs.
Overview of Asphyxia Neonatorum
Asphyxia neonatorum, also known as newborn asphyxia or birth asphyxia, refers to a condition characterized by respiratory failure in newborns due to inadequate intake of oxygen before, during, or immediately after birth. Asphyxia neonatorum poses a major global health challenge, with millions of cases reported annually. In the United States, it is considered the tenth leading cause of infant death, with a reported rate of 14.4 deaths per 100,000 live births in 2002.
The pathogenesis of asphyxia neonatorum involves various factors that contribute to the insufficient oxygen supply during the perinatal period. Prenatal hypoxia, resulting from reduced oxygen levels despite adequate blood perfusion to the tissues, is a common cause. Other factors include umbilical cord compression during childbirth, difficult delivery, maternal anesthesia, and high-risk pregnancies.
Fig.1 Risk factors for birth asphyxia. (Bayih, et al. 2021) Diagnostics Development of Asphyxia Neonatorum
Diagnostic methods have evolved over the years, to provide objective assessments of the newborn's health status and identify the severity of the condition.
- Apgar Score: One widely used tool is the Apgar score, which evaluates the infant's respiration, heart rate, muscle tone, skin color, and reflexes shortly after birth.
- Imaging Examination: Magnetic resonance imaging (MRI) and electroencephalography (EEG) enable detailed assessment of brain function and structure.
- Biochemical Detection: Biomarker analysis, including blood gases, lactate levels, and neurotrophic factors, shows promise in identifying asphyxia neonatorum and assessing its severity.
Therapeutics Development of Asphyxia Neonatorum
- Targets of Asphyxia Neonatorum Therapy Development
Nervous System Damage Pathways
Brain damage caused by reduced oxygen and blood supply is an important feature of asphyxia neonatorum. Drugs that target pathways of neurological damage, such as excitatory amino acid antagonists and anti-inflammatory drugs, can minimize brain damage and promote healthy neurodevelopment in affected infants.
Respiratory Resuscitation Pathways
Prompt and effective respiratory resuscitation is critical for infants who are unable to begin breathing normally and require immediate intervention to restore oxygenation. Medications used for respiratory resuscitation, such as epinephrine, play a vital role in supporting neonates with asphyxia neonatorum.
- Types of Asphyxia Neonatorum Therapy Development
- Stem Cell Therapy Development
The regenerative and immunomodulatory properties of stem cells offer the potential to repair damaged tissue and mitigate the long-term consequences of asphyxia neonatorum. Preclinical studies utilizing various types of stem cells, such as mesenchymal stem cells (MSCs) and neural stem cells, have shown promising results in reducing brain damage and promoting functional recovery in animal models of asphyxia neonatorum.
Our Services
Our company leads the way in rare disease research and the development of therapeutics. With a team of experienced scientists and researchers, we have established the advanced platforms dedicated to unraveling the complexities of rare diseases, including asphyxia neonatorum.
Our research platforms
Our company is dedicated to offering diagnostic development services that facilitate early detection and precise diagnosis of asphyxia neonatorum. Recognizing the significance of animal models in therapeutic drug development, we specialize in constructing animal models for asphyxia neonatorum. These models enable our customers to conduct drug safety evaluation and pharmacokinetics study on potential drug candidates.
Animal Models of Asphyxia Neonatorum
- Rodent model (mice, rats, rabbits, etc.)
- Non-human primate model (monkeys, orangutans, etc.)
- Large animal models (sheep, lamb, puppy, piglet, etc.)
Regardless of your current research stage, we offer comprehensive research services tailored to your needs. If you are interested in our services, please don't hesitate to contact us for more information and a detailed quotation regarding the specific services you require.
References
- Bayih, Wubet Alebachew, et al. "The state of birth asphyxia in Ethiopia: An umbrella review of systematic review and meta-analysis reports, 2020." Heliyon 7.10 (2021).
- Improda, Nicola, et al. "Perinatal asphyxia and hypothermic treatment from the endocrine perspective." Frontiers in Endocrinology 14 (2023): 1249700.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.