Pharmacokinetics Services
Pharmacokinetics mainly studies the movement of drugs in the body. Our company has a group of experienced and high-level scientists who are good at pharmacokinetic studies. We can provide a complete set of in vivo and in vitro pharmacokinetic study services from experimental design, implementation, and analysis, and provide customers with a full range of pharmacokinetics services to accelerate your rare disease therapy development.
Introduction to Pharmacokinetics
Pharmacokinetics (PK) describes the absorption, distribution, metabolism, and excretion characteristics of drugs, which are collectively called "ADME". Pharmacokinetics (PK) can be studied together with pharmacodynamics (PD), which is the study of the effects of drugs on the body. PK/PD can be thought of as an exposure/response relationship and is key to the development and approval of every drug. PK studies can also help determine the efficacy characteristics of drugs.
The Principle of ADME
When drugs are absorbed by the human body, the molecular size and structure, the permeability of the gastrointestinal membrane, etc. affect the degree and rate of absorption. After absorption, it is transported from the blood to various tissues and organs. The study of the distribution in the body helps to understand the dosage and form of the drug. Afterward, the drug is metabolized by the body, and common types of reactions are oxidation, hydrolysis, reduction, and conjugation. The ultimate goal of metabolism is to facilitate the excretion of drugs from the body, otherwise, accumulation of the drug in the blood will lead to toxicity.
Fig.1 Summary of ADME properties. (Ferreira, A., et al., 2021) Application of Pharmacokinetics
- For new drug discovery.
- Assess changes in dose requirements.
- Determine drug safety and efficacy characteristics.
- Provide support for research on pharmaceutical formulations.
- For medication guidance.
Our Services
Our company has the most advanced equipment and technology, can provide in vivo and in vitro model development services, and can perform a full range of pharmacokinetic services from drug discovery to preclinical research to accelerate your research on the therapeutics of rare diseases.
Our company has highly experienced and mature scientists capable of performing the entire set of services from drug discovery to preclinical studies to accelerate in vitro ADME studies for the therapeutics of rare diseases.
In Vivo Pharmacokinetics Services
In vivo pharmacokinetics is mainly used to study the preclinical pharmacokinetics of drugs in experimental animals. Our company can provide efficient methods to accelerate your rare disease therapy development.
Service Highlights
- Professional team with many years of experience in pharmacokinetics
- Providing standardized upstream platform solutions
- Competitive pricing and fast turnaround time
- Advanced platforms and reliable analysis
- High-quality one-stop service
Project Workflow
Our company has a long-term commitment devoted to the study and application of pharmacokinetics of rare disease drugs. We customize personalized solutions and analysis processes according to your different scientific research needs and track the progress of projects in real-time to accelerate your rare disease therapy research and development. If you are interested in our services, please feel free to contact us for more information.
Reference
- Ferreira, A., et al. "PBPK modeling and simulation and therapeutic drug monitoring: Possible ways for antibiotic dose adjustment." Processes 9.11 (2021): 2087.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.