Bipolar Disorder
Bipolar disorder is a persistent mood disorder characterized by significant fluctuations in mood, energy, and behavior. Our company is dedicated to advancing the research of bipolar disorder. Our experienced team of researchers and scientists tirelessly develops innovative diagnostic and therapeutic approaches to manage this debilitating disease. We are your trusted partner in bipolar disorder research, providing a streamlined and comprehensive solution for all your scientific research needs.
Introduction to Bipolar Disorder
Bipolar disorder, also known as manic depression, is a complex mental disorder characterized by recurring episodes of depression and abnormally elevated mood. The exact incidence of bipolar disorder can vary depending on the population being studied and the methodology used to collect data. Evidence suggests that the global lifetime prevalence of bipolar disorder is approximately 1% and the one-year prevalence is approximately 0.5%.
Fig. 1 Inflammatory signaling mechanisms in bipolar disorder. (Jones, et al., 2021)Pathogenesis of Bipolar Disorder
Bipolar disorder is believed to have strong associations with genetic factors, environmental influences, and neurological impairment.
Genetic Factors
Genetic factors contribute to approximately 73% to 93% of the risk associated with developing bipolar disorder. Bipolar disorder is associated with polymorphisms in several genes, including BDNF, DRD4, DAO, and TPH1.
Environmental Influences
Environmental factors also contribute to the manifestation of bipolar disorder. Stressful life events, such as trauma, chronic stress, experiences of abuse, etc., may trigger depressive or manic episodes in individuals susceptible to the disorder.
Neurological Impairment
While less common, bipolar disorder can also be attributed to neurological diseases or injuries, including stroke, traumatic brain injury, HIV infection, multiple sclerosis, porphyria, etc.
Diagnostics Development of Bipolar Disorder
Diagnostic methods for bipolar disorder primarily involve symptom assessment and differential diagnosis. Symptom assessment aims to identify the existence and intensity of manic, hypomanic, and depressive episodes. Differential diagnosis plays a crucial role in distinguishing bipolar disorder from other conditions that may exhibit similar symptoms.
In recent times, there has been growing enthusiasm for the advancement of biomarkers for bipolar disorder. These biomarkers, such as genetic markers, neuroimaging techniques, and blood tests, promise to improve diagnostic accuracy, predict therapeutic response, and guide personalized therapies.
Therapeutics Development of Bipolar Disorder
- Targets of Bipolar Disorder Therapy Development
| Target | Description |
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| Regulate Neurotransmitters | Neurotransmitters like dopamine, serotonin, and norepinephrine play crucial roles in mood regulation and are often dysregulated in individuals with bipolar disorder. Medications targeting these neurotransmitter systems aim to restore the balance and alleviate symptoms associated with the disorder. For example, mood stabilizers like lithium act by modulating neurotransmitter release and receptor sensitivity, helping to stabilize mood swings. |
| Neuroinflammatory Pathways | Studies have shown that neuroinflammation, characterized by elevated levels of pro-inflammatory molecules in the brain, may contribute to the pathophysiology of the disorder. Therapeutics aimed at reducing neuroinflammation, such as anti-inflammatory drugs and immune-modulating agents, are being explored as potential therapeutic options. |
- Therapeutic Drugs for Bipolar Disorder
Lithium
Lithium is an effective mood stabilizer that helps lower the risk of relapse and decrease the frequency and intensity of manic and depressive episodes.
Anticonvulsant Medications
Valproate, carbamazepine, and lamotrigine are commonly prescribed for mood stabilization and the prevention of manic and depressive episodes.
Atypical Antipsychotics
Olanzapine, quetiapine, risperidone, and aripiprazole are among the atypical antipsychotics approved for the therapeutics of acute manic episodes.
Our Services
Our company has established a comprehensive platform for developing rare disease diagnostics and therapies, encompassing small molecule drug, cell therapy, gene therapy, therapeutic antibody, therapeutic peptide, and therapeutic protein. Through our dedicated platforms, we are fully devoted to advancing the development of innovative diagnostic tools and therapies for bipolar disorder.
Recognizing the significance of animal disease models in the therapy development for bipolar disorder, we used genetic manipulation, induction of chronic stress, administration of mood-altering drugs, and disruption of circadian rhythms to construct animal models of bipolar disorder. These models serve as invaluable tools to facilitate the safety evaluation and pharmacokinetics study of your drug candidates.
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| Our company is committed to the advancement of transgenic animal models for bipolar disorder. Our team of scientists has successfully created transgenic mice with modifications in dopamine or serotonin signaling pathways, disrupted circadian rhythms, and mutations in genes implicated in bipolar disorder. | ||||
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| Optional Species | Mice, Rats, Zebrafish, Pigs, Ferrets, Others | |||
If you are interested in our services, please don't hesitate to contact us for more information and a detailed quotation regarding the specific services you require.
References
- Jones, Gregory H., et al. "Inflammatory signaling mechanisms in bipolar disorder." Journal of Biomedical Science 28 (2021): 1-22.
- Li, Xinyu, et al. "A novel murine model of mania." Molecular psychiatry 28.7 (2023): 3044-3054.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.