Chemical-induced Animal Model Development
A chemical-induced animal model refers to a type of experimental model in which a certain disease or condition is provoked in animals by the use of chemical substances. These models demonstrate the features and characteristics of the diseases, enabling the researchers to examine the pathology of the particular disease and its possible cures which are a foundation for basic science and drug development.
Protheragen devotes offer specific services for the construction of chemically induced models of rare cardiovascular diseases by providing necessary resources to researchers and scientists for purposes of therapeutic development.
Overview of Chemical-induced Animal Models
In models induced with chemicals, animals are subjected to certain chemicals that create physiological or pathological conditions similar to the disease features. The development of chemical-induced cardiovascular models usually begins with the specific selection of agents known to induce disease-causing mutations or changes in biological pathways. Chemical-induced model is achieved through the deliberate control over the dosage and timing of the chemical exposure which allows the recreation of specific objectives in the disease process in animal models and the study of the disease mechanisms, progression, and therapies.
Fig.1 Monocrotaline-induced pulmonary arterial hypertension rat model. (Hołda, M. K., et al., 2022)Advantages of Chemical-induced Animal Models
Precision and Repeatability
Models using chemical induction permit precision concerning dose, time, and exposure which leads to highly reproducible results. Which allows tailor the induction protocol to mimic specific pathological features.
Rapid Model Development
In contrast to genetically or surgically induced models, chemical induction usually leads to disease features appearing more rapidly, thereby accelerating the research timeline.
Accessibility
Compared to other types of modeling approaches, chemical induction usually requires lesser complex techniques and simpler equipment. This also serves to reduce the total cost of model development.
Our Services
At the forefront of animal model development, we create various chemical-induced models using advanced technologies with strict development processes at different levels. We control the dose of the chemicals administered, the timing of administration, and the method of administration (oral, topical, or injection). These models are valuable resources for cardiovascular disease research and allow for studying disease processes, targets, and the impact of various interventions.
Chemical-induced Animal Models Available at Our Company
Various chemical induction model development services for rare cardiovascular diseases are available, as shown in the table below. For the development of additional chemical-induced models for rare cardiovascular diseases, please contact us.
| Compound Name | Human Disease | Manipulation Method |
|---|---|---|
| Monocrotaline | Pulmonary Arterial Hypertension | Subcutaneous or intraperitoneal administration. |
| Adriamycin | Preeclampsia | Injection via the intraperitoneal route. |
| L-nitro-arginine | Preeclampsia | Continuous infusion through a venous catheter. |
| Elastase | Abdominal Aortic Aneurysms | Exposing a portion of the abdominal aorta and infusing it with elastase. |
| Calcium-Chloride | Abdominal Aortic Aneurysms | Calcium chloride is given peri-aortic in the space between the renal arteries and the iliac bifurcation. |
| Isoproterenol | Diffuse-myocardial necrosis | A solitary subcutaneous injection. |
Chemical-induced Animal Model Development Services
Types of Disease Models
- Rare Arrhythmias
- Rare Cardiomyopathies
- Rare Congenital Heart Diseases
- Rare Vascular Diseases
- Rare Cardiac Tumors
- Other Cardiovascular Diseases
Animal Species Selection
- Mouse Model
- Rat Model
- Rabbit Model
- Zebrafish Model
- Pig Model
- Non-human Primates
- Others
Why Choose Us?
- Precision
Particular chemical-induced models with the accurate features of rare cardiovascular diseases provide substantial relevance and reliability for conducted research studies.
- Customization
Flexible services provided are tailored to the needs of individual research projects based on specific disease models and particular study goals set.
- Expertise
A fully equipped team of knowledgeable scientists and researchers ensures the attainment of high-quality and scientifically accurate results.
Combining our knowledge with our vast industry experience, Protheragen provide services for the development of chemical-induced animal models for rare cardiovascular diseases. These models are appropriate for preclinical studies for the testing of the pharmacodynamics, pharmacokinetics, and safety of drugs for diseases of the heart and their associated organs. Please do not hesitate to contact us again if you seek another type of further information or specific pricing.
Reference
- Hołda, Mateusz K et al. "Changes in heart morphometric parameters over the course of a monocrotaline-induced pulmonary arterial hypertension rat model." Journal of translational medicine 18.1 (2020): 262.
For research use only, not for clinical use.