Transplant Animal Model Development
The study and mitigation of rare forms of cardiovascular diseases necessitate the development of therapies, which makes transplant animal models and their study vital. Protheragen, as a research service provider, offers bespoke transplant animal model development services for rare cardiovascular diseases. Together with researchers and pharmaceutical companies, we endeavor animal models that possess certain human pathologies to promote the timely development of effective therapies.
Overview of Transplant Animal Models
Transplant animal models are experimental systems that utilize the transplantation of human or animal tissues into a recipient organism for the study of rare cardiovascular diseases, including their pathophysiology, progression, and therapy. These models closely resemble humans allowing a comprehensive understanding of the disease processes and drug efficacy which enhances the development of targeted and effective interventions thus improving the prognosis and quality of life of individuals with these intricate cardiovascular problems.
Fig.1 Schematic representation of aorta transplant model. (Liu, Z., et al., 2015)Types of Transplant Animal Models for Rare Cardiovascular Diseases
Transplant animal models serve as crucial instruments in the study of uncommon cardiovascular disorders as they aid in the elucidation of their pathophysiology and the development of novel therapeutics. Different types of transplant models for various diseases are classified depending on the origin of the tissue or cell that is transplanted.
Allograft Model
An allograft model consists of the transplantation of cells, tissues, or organs from one individual to another individual of the same species but with a different genetic composition.
Xenograft Model
A xenograft model is the transplantation of cells, tissues, or organs from one species to another. An example would be the implantation of human tumor cells or tissues in immunodeficient mice.
Our Services
With our modern technology and knowledge of cardiovascular biology, we intend to improve personalized therapeutics for uniquely rare cardiovascular disorders. Our transplant animal model development services for the animal of specific human cardiovascular which provide a platform for pathologies to mimic disease mechanisms and complete support for scientists working on drug efficacy, pharmacokinetics, and drug safety.
Transplant Animal Models Available at Our Company
The subsequent table illustrates some of the transplant animal models that we can offer. Please contact us for the development of other rare cardiovascular disease transplant models.
| Human Disease | Type | Description |
|---|---|---|
| Abdominal aortic aneurysm | Xenograft model | A guinea pig's abdominal aorta is removed, decellularized with a detergent, and then grafted to a rat. |
| Abdominal aortic aneurysm | Allograft model | An aorta from a mouse is elastase treated and then transplanted to a recipient mouse where it is allowed to develop an aneurysm. |
| Venous malformation | Xenograft model | Endothelial cells from a patient are injected subcutaneously into the back of athymic nude mice for the generation of ectatic vascular channels. |
| Arteriovenous malformations | Xenograft model | Human arteriovenous malformation specimens collected from patients are sectioned and xenografted subcutaneously in immunodeficient nude mice. |
Transplant Animal Model Development Services
Types of Transplant Animal Models
- Allograft Model Development
Cell line-derived allograft (CDA)
Mouse-derived allograft (MDA)
- Xenograft Model Development
Cell line-derived xenograft (CDX)
Patient-derived xenograft (PDX)
Types of Disease Models
- Rare Vascular Diseases
- Rare Cardiac Tumors
- Other Cardiovascular Diseases
Our Advantages
- Tailored Solutions
Collaborate with clients to ascertain their precise research requirements so that we can create bespoke models for their projects.
- Expertise
Deep insights into cardiovascular diseases ensure that our models are applicable and scientifically accurate.
- Advanced Technology
Improve model fidelity and reproducibility using state-of-the-art technologies and methods to reliable the research outcomes.
Protheragen leverages advanced engineering techniques and biological samples obtained ethically to fabricate novel animal models vital for detailed studies of cardiovascular disease mechanisms and drug action. Should there be any query regarding services offered, we welcome you to reach out for assistance and obtain further details.
Reference
- Liu, Zhenjie et al. "Murine abdominal aortic aneurysm model by orthotopic allograft transplantation of elastase-treated abdominal aorta." Journal of vascular surgery 62.6 (2015): 1607-14.
For research use only, not for clinical use.