Cerebral Palsy
Cerebral palsy is a group of movement disorders that appear in early childhood. Our company boasts a highly skilled team of researchers and scientists who possess extensive expertise in the study of cerebral palsy. This expertise serves as the cornerstone for the development of groundbreaking diagnostic tools and therapeutic drugs. As a trusted and dependable partner, our company provides a comprehensive range of customized services to cater to your unique scientific research needs.
Introduction to Cerebral Palsy
Cerebral palsy is a group of neurological conditions characterized by motor disabilities and movement disorders. It affects muscle tone, posture, and voluntary muscle control. Cerebral palsy is a relatively rare condition, with an estimated prevalence of 2 to 3 cases per 1,000 children. It can result in challenges related to coordination, balance, and mobility, significantly impacting the affected individuals' daily lives.
Pathogenesis of Cerebral Palsy
Cerebral palsy is usually caused by abnormal brain development or damage to the developing brain. The causes of this condition are likely multifactorial and occur at various stages of development. Factors such as prenatal infections, genetic abnormalities, maternal health conditions, birth complications, and brain injuries can contribute to the development of cerebral palsy.
Research has shown that approximately 80% of cerebral palsy cases are attributed to damage that occurs before birth. This includes disruptions in fetal brain development, congenital malformations, infections in the central nervous system, strokes, genetic issues, and inadequate blood flow or oxygen supply to the fetal brain. The 10% of cases occur due to postnatal events such as accidental injuries, physical abuse, infections, and jaundice. The reasons for the remaining 10% are unknown.
Fig.1 Musculoskeletal pathology in cerebral palsy. (Graham, et al. 2021)Diagnostics Development of Cerebral Palsy
The diagnosis of cerebral palsy mainly involves medical evaluation and diagnostic tests.
Medical Evaluation
The medical evaluation mainly examines the child's mobility, speech, hearing, etc., and also evaluates the medical history and family history.
Diagnostic Test
Diagnostic tests mainly include brain imaging techniques such as MRI or CT scans and electroencephalography (EEG), which can assess motor skills, muscle tone and coordination.
Therapeutics Development of Cerebral Palsy
The therapeutic development for cerebral palsy aims to improve motor function, manage associated symptoms, and enhance the quality of life for individuals with cerebral palsy. Several targets are being pursued in cerebral palsy therapy development.
| Target Name | Description |
|---|---|
| Spasticity and Muscle Tone Relief Pathways | Spasticity, characterized by muscle stiffness and involuntary contractions, is a common symptom of cerebral palsy. Therapies for spasticity in cerebral palsy aim to decrease muscle tone and enhance flexibility, enabling smoother and more controlled movements. Common approaches include muscle relaxants, antispasmodics, and botulinum toxin injections, all of which are utilized to manage spasticity and improve overall motor function. |
| Neuroplasticity and Neural Repair Pathways | Therapies are focused on promoting neuroplasticity and neural repair to enhance the development and function of the brain. This includes interventions that stimulate the growth and connectivity of neurons, such as activity-based therapies, constraint-induced movement therapy, and repetitive transcranial magnetic stimulation. |
Our Services
Our company leads the way in rare disease research and therapeutic development. We are committed to providing a comprehensive and integrated solution for diagnostic research and the development of therapeutics for cerebral palsy.
Diagnostic Development Service
Our company provides diagnostic development services to assist you in developing advanced diagnostic tools for cerebral palsy to facilitate early identification and accurate diagnosis of the disease.
Therapeutic Development Service
Our company provides a wide range of services for the development of small molecule drug, cell therapy, gene therapy, therapeutic antibody, therapeutic peptide, and therapeutic protein to accelerate your research on cerebral palsy therapy.
Animal Model Development Service
We offer a variety of animal models for cerebral palsy therapeutic research.
- Establishment of rabbit cerebral palsy models by induced brain injury
- Establishment of mouse/rat cerebral palsy models through hypoxia/ischemia/
infection/inflammation
If you are interested in our services, please don't hesitate to contact us for more information and a detailed quotation regarding the specific services you require.
References
- Graham, H. Kerr, et al. "Musculoskeletal pathology in cerebral palsy: a classification system and reliability study." Children 8.3 (2021): 252.
- Ornoy, Asher. "Animal models of cerebral palsy: What can we learn about cerebral palsy in humans." Cerebral Palsy (2020): 85-96.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.