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Drug Metabolism & Pharmacokinetics Service

The examination of drug metabolism and pharmacokinetics (DMPK) in drug development is crucial in the early stages of the development program. An appropriate DMPK analysis of the candidate drug may greatly determine the success of a drug discovery program. Protheragen integrates in vivo sample generation and bioanalysis, offering a broad scope of customized DMPK services for small molecules, large molecules, peptides, and biologics related to mitochondrial disease.

Our Services

Our drug metabolism and pharmacokinetics (DMPK) services provide the needed service to pharmaceutical firms, biotech companies, and university researchers working on the therapeutic areas of mitochondrial diseases. At Protheragen, we offer high-quality and efficient DMPK screening assays for all your drug discovery needs with fast turnaround times.

In Vitro DMPK Assays In Vitro DMPK Assays

Using sophisticated in vitro assay platforms, we study the metabolic stability and the drug-drug interactions, as well as the pharmacokinetic properties of the candidate compounds. These assays can assess the absorption, distribution, metabolism, and excretion (ADME) of drugs about mitochondrial dysfunction.

In Vivo Pharmacokinetic Studies In Vivo Pharmacokinetic Studies

Through the relevant animal models of mitochondrial diseases, our in vivo pharmacokinetic studies assess the bioavailability, tissue distribution, and systemic clearance of potential drug candidates. Defining the pharmacokinetic profile of the compounds in vivo greatly enhances decision-making throughout the entire drug development process.

The team at Protheragen, being experts in the field of mitochondrial diseases, possesses the necessary experience and expertise to deliver professional, efficient, and dependable ADME services.

  • Drug Absorption Service
    Drug absorption studies can establish the levels of a drug that is captured in the body’s system after oral, injection, or topical administration. This information is important for calculating the dosage of a drug and knowing its toxicological risks.
  • Drug Distribution Service
    The systemic distribution of drugs can be assessed for the period after the absorption phase and is important in understanding the behavior of the drug trajectory toward its intended target and the possible side effects.
  • Drug Metabolism Service
    The investigation of drug metabolism focuses on the enzymes that bring about the metabolism of the drug and the resulting metabolites. This information is vital in understanding the half-life of the drug, its interactions with other drugs, and its safety and efficacy.
  • Drug Excretion Service
    Analyzing the excretion phase of the drug provides information on the elimination routes, like through urine or feces, which are important from the perspectives of understanding the pharmacokinetics of the drug and also the toxicological consequences when they arise.

Our Advantages

Professional Team

Professional Team

Advanced Technology

Advanced Technology

Comprehensive Services

Comprehensive Services

Reliable Data and Results

Reliable Data and Results

If you are looking for thorough DMPK support for early discovery or intensive pharmacokinetics profiling for your research project, we are focused on providing tailored solutions for all your requirements. Contact us and find out how our drug metabolism & pharmacokinetics service can accelerate the development of your drugs for mitochondrial disease.

For research use only, not for clinical use.