Analyzing drug metabolism & pharmacokinetics (DMPK) plays a crucial role in the initial stages of drug development. A comprehensive understanding of DMPK for a potential candidate drug can significantly impact the success of a drug discovery program. Protheragen seamlessly offers integrated services for in vivo sample generation and bioanalysis, providing an extensive range of tailored DMPK services for mitochondrial disease encompassing small molecules, large molecules, peptides, and biologics.
Our Services
Our Drug Metabolism & Pharmacokinetics (DMPK) Service is specifically designed to offer comprehensive support to pharmaceutical companies, biotech firms, and academic researchers engaged in the field of mitochondrial disease therapeutics. At Protheragen, we provide high-quality and efficient DMPK screening assays for your drug discovery endeavors with a rapid turnaround time.
In Vitro DMPK Assays
By utilizing advanced in vitro assay platforms, we assess the metabolic stability, drug-drug interactions, and pharmacokinetic properties of candidate compounds. These assays offer valuable insights into the absorption, distribution, metabolism, and excretion (ADME) of drugs within the context of mitochondrial dysfunction.
In Vivo Pharmacokinetic Studies
Our in vivo pharmacokinetic studies employ relevant animal models of mitochondrial diseases to evaluate the bioavailability, tissue distribution, and systemic clearance of potential drug candidates. By accurately characterizing the compounds' pharmacokinetic profile in vivo, we facilitate informed decision-making throughout the drug development process.
The team at Protheragen, being experts in the field of mitochondrial diseases, possesses the necessary experience and expertise to deliver professional, efficient, and dependable ADME services.
- Drug Absorption Service
Drug absorption studies can be utilized to ascertain the extent of drug assimilation into the systemic circulation following oral, topical, or injectable administration. This data holds significance in determining the optimal dosage regimen and mitigating potential toxicological risks.
- Drug Distribution Service
The distribution of drugs can be investigated to monitor their systemic dissemination following absorption, which is crucial for comprehending the drug's trajectory toward its intended target and identifying potential adverse reactions.
- Drug Metabolism Service
The study of drug metabolism can be utilized to identify the specific enzymes responsible for metabolizing a drug as well as the resulting metabolites. This valuable information plays a crucial role in comprehending the drug's half-life, potential interactions with other drugs, and its overall safety and effectiveness.
- Drug Excretion Service
The analysis of drug excretion can provide valuable insights into the elimination pathways, including renal and fecal routes, which are crucial for determining the drug's pharmacokinetics and potential toxicological implications.
Our Advantages
Professional Team
Advanced Technology
Comprehensive Services
Reliable Data and Results
Whether you require comprehensive DMPK support for early-stage discovery or in-depth pharmacokinetic profiling for clinical candidates, we are dedicated to providing innovative solutions tailored specifically to meet your needs. Contact us today to discover how our dug metabolism & pharmacokinetics service can expedite the development of your mitochondrial disease drugs.
