In addition to mitochondrial diseases caused by mutations in genes essential for mitochondrial function, mitochondrial impairments have been associated with various age-related disorders such as neurodegenerative diseases, cardiovascular diseases, cancer, and diabetes. Therefore, there is a greater emphasis on conducting in vivo and in vitro studies of mitochondria. Protheragen is committed to advancing the understanding of Mitochondrial Diseases (MDs) through the creation and utilization of state-of-the-art cellular and animal models.
Different Types of Mitochondrial Disease
Prominent characteristics of diverse model systems for studying mitochondrial diseases, in addition to their respective advantages and limitations.
- Disease phenotypes
- Intervention bioavailability & PK/PD
- Translatable dietary intake studies
- Disease progression
- Organ system effects
- Toxicology
- Disease progression
- Survival & lifespan
- Organ system effects
- Ease of organ system morphology & microscopy analysis (zebrafish)
- Disease phenotypes
- Survival & lifespan
- Genetic screens & interactions
- Organ system effects (flies)
- Tissue outputs (worms)
- Patient-specific phenotypes
- Ease of biochemical interrogations
- In vitro genetic & drug screens
- Ease of microscopic analysis of mitochondrial morphology & dynamics
Our Services
Various cell and animal models are utilized to comprehensively investigate the pathogenesis and etiology of mitochondrial diseases. Protheragen offers customizable modeling services tailored to meet the specific needs of our customers.
Cell-Based Model Development Service
Our cell-based model development service creates in vitro models that mimic the mitochondrial disease environment in cells. These models are essential for understanding the cellular mechanisms of mitochondrial dysfunction and for screening potential therapeutic agents.
Animal Model Development Service
Our animal model development service provides in vivo models that replicate mitochondrial disease phenotypes. These models are crucial for studying disease progression and evaluating the efficacy of new treatments in a physiological context.
Our Advantages
- Tailored Precision
Our team of experienced scientists excels in developing highly customized models that accurately replicate the genetic and phenotypic characteristics of specific mitochondrial diseases. This tailored precision ensures seamless alignment between your research objectives and our deliverables.
- Comprehensive Genetic Representation
The spectrum of genetic variations observed in mitochondrial disorders is extensive. Our models distinguish themselves by incorporating diverse genetic backgrounds, thereby providing a more comprehensive representation of the genetic diversity associated with mitochondrial diseases.
- Cutting-Edge Technologies
Embrace the future of mitochondrial disease research through our integration of cutting-edge technologies, encompassing advanced gene editing techniques, state-of-the-art CRISPR/Cas9 applications, and targeted interventions for mitochondria. We consistently remain at the forefront of technological advancements.
Ready to elevate your research capabilities in mitochondrial disease modeling? If you are interested in our services, please don't hesitate to contact us.
