Besides mitochondrial diseases inflicted by mutations in genes essential for mitochondrial function, there are also mitochondrial impairments associated with aging, such as neurodegenerative diseases, cardiovascular diseases, cancers, and diabetes. As a result, there is more focus on performing in vivo and in vitro experiments on the mitochondria. Protheragen strives to shed light on mitochondrial diseases through the development and application of innovative cellular and animal models.
Different Types of Mitochondrial Disease
Prominent characteristics of diverse model systems for studying mitochondrial diseases, in addition to their respective advantages and limitations.
- Disease phenotypes
- Intervention bioavailability & PK/PD
- Translatable dietary intake studies
- Disease progression
- Organ system effects
- Toxicology
- Disease progression
- Survival & lifespan
- Organ system effects
- Ease of organ system morphology & microscopy analysis (zebrafish)
- Disease phenotypes
- Survival & lifespan
- Genetic screens & interactions
- Organ system effects (flies)
- Tissue outputs (worms)
- Patient-specific phenotypes
- Ease of biochemical interrogations
- In vitro genetic & drug screens
- Ease of microscopic analysis of mitochondrial morphology & dynamics
Our Services
Various cell and animal models are utilized to comprehensively investigate the pathogenesis and etiology of mitochondrial diseases. Protheragen offers customizable modeling services tailored to meet the specific needs of our customers.
Cell-Based Model Development Service
The cell-based model development services of our company generate in vitro models that replicate the environment of mitochondrial diseases. These models are vital for studies dealing with the pathophysiology of mitochondrial defects and for exploring possible therapeutic agents.
Animal Model Development Service
The animal model development services of our company offer in vivo models that replicate phenotypes of mitochondrial diseases. These models are essential for studying the disease progression and assessing the effectiveness of novel interventions in a physiological context.
Our Advantages
- Tailored Precision
A team of veteran professionals specializes in developing specialized and customized models to suit the needs of specific mitochondrial diseases on a genetic and phenotypic level. This tailored accuracy, as mentioned above, assures that your research goals perfectly match our deliverables.
- Comprehensive Genetic Representation
The range of genetic variations seen in mitochondrial disorders is extensive. Our models are unique because they include different genetic backgrounds, which provides a better comprehensive representation of the genetic diversity associated with mitochondrial diseases.
- Cutting-Edge Technologies
Adopting the most advanced methods in advanced genetic manipulation, powerful and modern gene editing techniques, and targeted interventions for mitochondria by other sophisticated methods to embrace the future of mitochondrial disease research.
Ready to elevate your research capabilities in mitochondrial disease modeling? If you are interested in our services, please don't hesitate to contact us.
