Professional medical and pharmacological researchers across the globe are giving immense attention to novel drug innovations for mitochondrial disease research. Identifying new targets related to mitochondrial diseases is seen as a critical step towards innovative drug development. Protheragen provides an integrated solution for target identification and validation helping the clients accelerate their mitochondrial diseases drug discovery process.
Targets Associated with Mitochondrial Diseases
Recognizing relevant targets for mitochondrial diseases is essential for developing effective therapy methodologies. A comprehensive list concerning mitochondrial disorder targets is provided beneath.
| Target |
Application |
| Mitochondrial DNA (mtDNA) Integrity |
Targeting mechanisms to maintain the stability of mtDNA. |
| Exploring pathways involved in the repair and replication of mtDNA. |
Oxidative Phosphorylation
Complexes |
Investigating subunits of Complexes I-V involved in the electron transport chain. |
| Targeting proteins that regulate ATP synthesis. |
| Mitochondrial Dynamics Proteins |
Drilling into proteins like mitofusins and dynamin-related proteins. |
| Understanding their role in mitochondrial fusion and fission events. |
| Mitochondrial Quality Control Pathways |
Targeting regulators of mitophagy for selective removal of damaged mitochondria. |
| Exploring pathways involved in mitochondrial biogenesis. |
| Mitochondrial Membrane Transporters |
Investigating proteins facilitating the transport of ions and metabolites across mitochondrial membranes. |
| Targeting transporters involved in maintaining mitochondrial homeostasis. |
| Regulation pathway of Mitochondrial Reactive Oxygen Species (ROS) |
Targeting antioxidant enzymes involved in ROS scavenging. |
| Exploring proteins that regulate ROS production within mitochondria. |
| Maintenance pathway of Mitochondrial Calcium Homeostasis |
Investigating proteins involved in regulating calcium levels within mitochondria. |
| Targeting channels and transporters regulating mitochondrial calcium influx. |
Our Services
The preliminary steps in the creation of new therapeutics for mitochondrial disorders include recognizing and confirming the targets associated with the disease. Protheragen has an up-to-date technological platform and provides customers with mitochondrial target discovery and validation services, including mitochondrial disease research.
Target Discovery Based on Genetic Biomarkers
Genomic analysis is done using advanced tools of sequencing and instrumentations for the analysis of genetic material. Bioinformatics techniques and data analysis techniques are used to identify potential biomarkers.
Target Discovery Based on Protein Biomarkers
The process of applying proteomics technology involves the identification and quantification of differential proteins in biological samples using mass spectrometry or protein microarrays.
Target Discovery Based on Enzyme Biomarkers
It is essential to conduct an in-depth and comprehensive enzyme analysis. This process is to identify therapeutic targets associated with specific diseases through the use of enzyme markers.
Our Advantages
Professional Team
Advanced Technology
Comprehensive Services
Reliable Data and Results
Protheragen excels in drug discovery and the development of mitochondrial disease. We have fully equipped research facilities and specialized teams to carry out comprehensive R&D services in all stages of novel drug discovery and development. We also offer fully customized solutions based on the requirements of our clients. If you are interested in availing our services, please feel free to contact us.
