The exploration of innovative drug research in the field of mitochondrial disease has emerged as a prominent area of interest for medical and pharmacological researchers worldwide. Identifying novel targets associated with mitochondrial diseases is considered a pivotal pathway toward the development of groundbreaking pharmaceuticals. Protheragen offers an all-encompassing platform for target identification and validation, facilitating clients in expediting their discovery process for novel drugs targeting mitochondrial diseases.
Targets Associated with Mitochondrial Diseases
The identification of pertinent targets in mitochondrial diseases is pivotal for the development of efficacious therapeutic interventions. Below is a comprehensive list of enumerating targets associated with mitochondrial diseases.
| Target |
Application |
| Mitochondrial DNA (mtDNA) Integrity |
Targeting mechanisms to maintain the stability of mtDNA. |
| Exploring pathways involved in the repair and replication of mtDNA. |
Oxidative Phosphorylation
Complexes |
Investigating subunits of Complexes I-V involved in the electron transport chain. |
| Targeting proteins that regulate ATP synthesis. |
| Mitochondrial Dynamics Proteins |
Drilling into proteins like mitofusins and dynamin-related proteins. |
| Understanding their role in mitochondrial fusion and fission events. |
| Mitochondrial Quality Control Pathways |
Targeting regulators of mitophagy for selective removal of damaged mitochondria. |
| Exploring pathways involved in mitochondrial biogenesis. |
| Mitochondrial Membrane Transporters |
Investigating proteins facilitating the transport of ions and metabolites across mitochondrial membranes. |
| Targeting transporters involved in maintaining mitochondrial homeostasis. |
| Regulation pathway of Mitochondrial Reactive Oxygen Species (ROS) |
Targeting antioxidant enzymes involved in ROS scavenging. |
| Exploring proteins that regulate ROS production within mitochondria. |
| Maintenance pathway of Mitochondrial Calcium Homeostasis |
Investigating proteins involved in regulating calcium levels within mitochondria. |
| Targeting channels and transporters regulating mitochondrial calcium influx. |
Our Services
Identification and validation of disease-associated targets are crucial steps in the development of novel drugs for mitochondrial diseases. With our advanced technological platform, Protheragen offers customers comprehensive services for identifying and validating mitochondrial targets and facilitating in-depth research on mitochondrial diseases.
Target Discovery Based on Genetic Biomarkers
The cutting-edge genomic analysis is conducted using state-of-the-art tools for sequencing and analyzing genetic material. Bioinformatics and data analysis techniques are employed to identify potential biomarkers.
Target Discovery Based on Protein Biomarkers
The application of proteomics technology involves the utilization of mass spectrometry or protein microarrays to identify and quantify differential proteins in biological samples.
Our Advantages
Professional Team
Advanced Technology
Comprehensive Services
Reliable Data and Results
Protheragen is a leading company in the field of drug discovery and development for mitochondrial disease. We possess state-of-the-art equipment platforms and have dedicated research teams, enabling us to offer comprehensive R&D services throughout the entire cycle of novel drug discovery and development. Our services are tailored to meet the specific needs of our clients. If you are interested in availing our services, please feel free to contact us.
