Induced Animal Model Development
An induced animal disease model is a research tool used to replicate the pathophysiological change of a specific disease in animals. Protheragen is actively engaged in the development of innovative approaches for the study of uncommon cardiovascular disorders. Our committed research services aim to develop induced animal models that are indispensable for the elucidation of these intricate phenomena and make possible the development of cardiovascular disorders in drug research.
Overview of Induced Animal Models
Induced animal disease models serve as experimental systems whereby a laboratory animal's disease state is artificially created through intervention. These models are designed to simulate, pathologic, hemodynamic, or immunologic aspects of the disease, providing insight into the disease mechanisms and corresponding therapeutical approaches, which rely on interventional methods other than direct genetic manipulation.
Types of Induced Animal Models for Rare Cardiovascular Diseases
The classification of rare cardiovascular disease induction models is typically based on both the underlying mechanism of disease initiation and the experimental approach used to replicate the disease phenotype. There are several classifications of induced disease models.
Chemical-induced Models
Pathological alterations in these models are initiated by the application of certain chemicals or drugs.
Diet-induced Models
These models rely on modification of the subjects' diet, like the introduction of a high-fat or high-sugar diet.
Environmental or Stress-induced Models
Certain models can result from exposure to specific environmental agents or stress like toxins, irradiation, or psychological strain.
Immunologically-induced Models
This model entails the injection of certain antigens along with adjuvants to stimulate the immune system, thus eliciting disease response.
Our Services
Animal experimentation plays a critical role in comprehending how diseases progress, novel drug development, and their associated therapy approaches. To assist in the experiments, our company provides certain kinds of induced animal model development services tailored to fit the requirements of the different projects, including but not limited to chemical induction, dietary induction, environmental or stress induction, and immune induction. These services strive to provide aid for the development of advanced drugs for unusual cardiovascular disorders.
Induced Animal Models Available at Our Company
The table below illustrates some of the induced animal model development services that we can offer. If you require animal models for other specific cardiovascular disease types, please don't hesitate to get in touch with us.
| Human Disease | Description | Types of Models |
|---|---|---|
| Familial Hypercholesterolemia | A high-cholesterol/high-fat (HCHF) diet is capable of causing severe hyperlipidemia and atherosclerotic lesions in the aorta and coronary arteries. | Diet-induced model |
| Pulmonary Hypertension | A single subcutaneous or intraperitoneal injection of monocrotaline is done to effect marked elevation of mean PA pressure. | Chemical-induced model |
| Pulmonary Hypertension | The combination of Sugen and chronic hypoxia for three weeks severely increases pulmonary hypertension. | Environmental or stress-induced model |
| Takotsubo Cardiomyopathy | Stress cardiomyopathy is produced by the immobilization (IMO) stress method in rats. | Environmental or stress-induced model |
| Congenital Heart Block | Antibodies targeting region 200-239 of Ro52 (p200) cause first-degree AV block and bradycardia. | Immunologically-induced model |
| Autoimmune Myocarditis | Treated with myosin heavy chain alpha peptides to create an experimental autoimmune myocarditis model. | Immunologically-induced model |
Induced Animal Model Development Services
Methods of Induced Model Development
- Chemical-induced Models
- Diet-induced Models
- Environmental or Stress-induced Models
- Immunologically-induced Models
- Other Models
Types of Induced Model Development
- Rare Arrhythmias
- Rare Cardiomyopathies
- Rare Congenital Heart Diseases
- Rare Vascular Diseases
- Rare Cardiac Tumors
- Other Cardiovascular Diseases
Why Choose Us?
- Ethical Considerations: We adhere to the most ethical standards in every aspect of our research. Animal models are constructed fully within the bounds of regulatory guidelines.
- Expertise: A team of competent researchers and scientists guarantees that relevant and efficient animal models, which are tailored to your research needs, are produced.
- Customized Solutions: Any research endeavor is unique in its objectives and scope, and as such, we provide full-fledged bespoke animal model development services.
At Protheragen, we are dedicated to providing world-class expert resources to help accelerate the development of your research. Our services include the development of specific induction models for particular rare cardiovascular diseases, detailed characterization and validation of animal models, and preclinical phase study support which encompasses pharmacodynamics, pharmacokinetics, and safety testing. To learn more about our service in induced animal model development, feel free to reach out to us.
Reference
- Boucherat, Olivier et al. "The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure." Circulation research 130.9 (2022): 1466-1486.
For research use only, not for clinical use.