Chromhidrosis
Chromhidrosis is a condition affecting the sweat glands, resulting in colored perspiration appearing on the face, underarms, or the areola of the breasts (the pigmented area surrounding the nipples). The sweat can exhibit hues of yellow, green, blue, brown, or black. Our company is well-equipped to address your drug and therapy development requirements in Chromhidrosis therapy.
Introduction to Chromhidrosis
Chromhidrosis is an uncommon disorder where individuals secrete colored sweat, usually from the apocrine glands. This condition typically affects areas with a high density of these glands, such as the face, armpits, and areolae. The exact prevalence is unclear, but it is deemed very rare, with only a few hundred documented cases in medical literature.
Pathogenesis of Chromhidrosis
The pathogenesis of chromhidrosis is not fully understood but is believed to involve the oxidation of lipofuscin, a pigment found in the apocrine glands. Factors such as emotional stress, physical exertion, and certain foods or medications can exacerbate the condition. Recent studies suggest that chromhidrosis may have a genetic component, although more research is needed to confirm this hypothesis.
Fig. 1 Various staining techniques aimed at lipofuscin pigments can provide histological evidence for diagnosing chromhidrosis. (Wang, A., et al., 2014)Diagnosis Development of Chromhidrosis
- One of the key developments is the application of next-generation sequencing (NGS) technologies. NGS allows for comprehensive genomic, transcriptomic, and epigenomic profiling at a high resolution, enabling the identification of genetic variants associated with chromhidrosis.
- Another promising technique is the use of liquid biopsies. This non-invasive method analyzes circulating biomarkers and exosomes from blood samples. Liquid biopsies have shown potential in diagnosing various diseases, including those with dermatological manifestations.
Therapy Development of Chromhidrosis
Small molecule drugs are often the first line of therapy for chromhidrosis due to their ease of administration and potential effectiveness. For example, capsaicin, a topical agent, can reduce colored sweat secretion by desensitizing nerve endings.
Monoclonal antibodies (mAbs) target specific proteins or receptors involved in chromhidrosis. Omalizumab (Xolair) targets immunoglobulin E (IgE) and may reduce sweat gland activity in inflammatory conditions.
Gene therapies aim to correct genetic abnormalities contributing to chromhidrosis. CRISPR/Cas9 can correct mutations or alter gene expression in apocrine gland cells, potentially reducing colored sweat production. RNA interference (RNAi) can silence specific genes involved in chromogenic compound production in sweat.
Cell therapies for chromhidrosis are still experimental, focusing on modifying sweat gland function. Mesenchymal stem cells (MSCs) may modulate the immune response and regenerate tissue, potentially altering apocrine gland behavior to reduce colored sweat.
Our Services
Our company embraces a partnership-driven approach. We work closely with clients to develop customized, innovative Chromhidrosis therapy strategies and provide strong support throughout the process.
Platforms of Chromhidrosis Therapy Development
Animal Models of Chromhidrosis
We possess established expertise in developing and using animal models that accurately replicate the disease characteristics and therapeutic responses. These models allow us to assess the safety and efficacy of potential therapies.
| Non-Genetically Engineering Models | ||
| We offer a variety of models tailored to specific research needs related to Chromhidrosis. These models enable researchers to simulate and investigate the complex biological processes involved in Chromhidrosis. | ||
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| Genetically Engineered Models | ||
| Our proficiency in genetic engineering techniques, including CRISPR/Cas9 technology, enables us to create precise and reliable models that replicate the genetic alterations seen in Chromhidrosis. | ||
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| Optional Species | Mice, Rats, Non-human primates, Others | |
Additionally, we can offer other comprehensive Animal models services that focus on specific signaling pathways and molecular targets.
If our services interest you, please contact us at your earliest convenience for more details.
References
- Wang, A., et al., "Chromhidrosis: a rare diagnosis requiring clinicopathologic correlation." Am J Dermatopathol, (2014). 36(10): p. 853-855.
- Kashetsky, N., et al., "Characteristics and treatment outcomes in chromhidrosis: A systematic review." J Am Acad Dermatol, (2021). 85(4): p. 998-1002.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.