Non-Genetically Engineering Model Development Services
Developing animal models has played a vital role in enhancing our comprehension of intricate rare diseases. Our organization specializes in delivering top-notch services for the creation of NON-GEMs, providing diverse model choices customized to meet specific research needs related to rare diseases. By employing non-genetic engineering methodologies, our company possesses the capability to develop NON-GEMs that faithfully replicate rare diseases, thereby expediting the advancement of targeted therapies and investigation into disease pathogenesis.
Introduction to Non-Genetically Engineering Models (NON-GEMs)
Non-genetically engineering models (NON-GEMs) are a category of animal models that aim to create simplified yet comparable representations of human physiology and diseases without genetic modification. The construction methods of NON-GEMs can be divided into physical, chemical, and biological methods.
- Physical factors involve subjecting animals to mechanical injury, surgery, radiation, or other physical means.
- Chemical factors encompass the use of chemical carcinogens (such as alkylating agents, nitrosamines, and aromatic amines), chemical poisoning, or excessive nutrient exposure to induce disease in animals.
- Biological factors involve the introduction of bacteria, microorganisms, parasites, or biotoxins (such as aflatoxin) that act as pathogens in animals.
Fig.1 Types of animal models. (Laaldin, N., et al., 2020)NON-GEMs for Rare Diseases
Rare diseases pose unique challenges due to their limited prevalence and lack of understanding. Through physical, chemical, and biological techniques, researchers can create animal models that exhibit characteristics of rare diseases, including metabolic disorders, neurodegenerative conditions, and lysosomal storage diseases. These models serve as valuable tools for investigating rare disease progression and identifying novel biomarkers. The following are examples of animal models of Parkinson's disease constructed through non-genetic engineering techniques:
Table 1 Non-genetically engineering models (NON-GEMs) of Parkinson's disease. (Su, Cheng-Fu, et al., 2021)
| Model | Mechanism | Behavior Deterioration | Major Usage of the Model | Disadvantages |
|---|---|---|---|---|
| MPTP-induced | A reduction of striatal DA and TH | Dyspraxia | To generate irreversible and severe motor abnormalities | No loss of neurons from locus coeruleus; lack of age-dependent, slow progressive lesion development |
| Rotenone-induced | Suppresses mitochondrial complex I | Impaired motor activity | To trigger deterioration of nigrostriatal DA as well as aggregated proteins like α-synuclein | Age-independent lesions |
| 6-OHDA-induced | Pro-oxidant properties, inhibits complex I activity | Rotational behavior | To induce motor impairment of limbs | Does not cross the BBB |
| Paraquat- and maneb-induced | Accelerates α-synuclein fibril formation | Impaired motor activity | To produce neuronal damage and a Parkinsonian-like syndrome | The dopaminergic toxicity is not selective |
Our Services
Our company assists researchers in selecting the most appropriate NON-GEMs for drug safety evaluation and pharmacokinetics research. Our team works closely with clients to customize the models based on rare disease specifications, including the choice of animal species, induction techniques, and disease phenotypes.
- Animal Species for Model Development
-Mouse
-Rat
-Rabbit-Pig
-Dog-Monkey
-Cat-Zebrafish
-Others - Methods of NON-GEMs Development
- Surgery Model Development: vascular catheterization, non-vascular catheterization, cardiac perfusion
- Induced Disease Model: chemical induction, radiation induction, physical agonist induction, special diet induction
- Types of NON-GEMs Development
- Circulatory System Disease Development Service
- Digestive System Disease Development Service
- Immune System Disease Development Service
- Motor System Disease Development Service
- Nervous System Disease Development Service
- Respiratory System Disease Development Service
- Urinary System Disease Development Service
Why Choose Us?
Our company provides comprehensive services and technical support for all stages of rare disease research. We utilize extensive experience in non-genetically engineering model (NON-GEMs) development to offer customized services and comprehensive assistance, facilitating the transition from rare disease therapy development to therapy commercialization. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Laaldin, N., et al. "Animal models: bridging cross-species variation through animal biotechnology." Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries. Academic Press, 2020. 183-207.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.