Necrotizing enterocolitis is a catastrophic digestive tract disease that causes intestine inflammation. This can interfere with the normal functioning of several bodily organs, leading to high rates of disease and even death. Protheragen, as a provider of research services for uncommon conditions affecting the gastrointestinal tract, offers comprehensive services customized to the requirements of various researchers and scientists in the field.

Introduction to Necrotizing Enterocolitis

Necrotizing enterocolitis is a rapid progressive intestinal destruction of an infant's immature intestines. This commonly occurs in the intestines of preterm and low-weight newborns with a prevalence of approximately 0.1%. Necrotizing enterocolitis has the propensity to develop necrotizing infection which further leads to sepsis, peritonitis, perforation, and in dire cases, demise. This condition affects preterm children at a disproportionate rate, having a mortality rate of approximately 25%.

Fig.1 Necrotizing enterocolitis risk factors. (Colarelli, A. M., et al., 2024)

Pathogenesis of Necrotizing Enterocolitis

Even though the cause of necrotizing enterocolitis remains unclear, it is well-known that prematurity is the main factor. This is because newborns with intrauterine growth restriction or preterm infants have intestines with poor peristalsis, high permeability, and low secretion of acid as well as digestive enzymes. These infants have low chances of survival due to the viability factors. Furthermore, the intestinal mucosa is damaged effortlessly and in the presence of inflammation, it can lead to total necrosis and perforation which subsequently triggers the systemic inflammatory response and results in neurodevelopmental and pulmonary complications.

Fig.2 Necrotizing enterocolitis therapy strategies. (Hu, X., et al., 2024)

Therapeutics Development for Necrotizing Enterocolitis

Disclaimer: Protheragen focuses on providing preclinical research services. This table is for information exchange purposes only. This table is not a treatment plan recommendation. For guidance on treatment options, please visit a regular hospital.

Our Services

Utilize novel technologies and approaches so that your research on necrotizing enterocolitis is on the cutting edge of science. Protheragen's modern facilities and equipment allow us to offer complete diagnostic and therapeutic development services. In addition, we provide customized disease model development services that allow researchers to recapitulate the pathogenesis of necrotizing enterocolitis in vitro and in vivo.

Therapeutic Development Services

Animal Model Development Services

Animal models the fundamental in studying necrotizing enterocolitis due to their ability to provide disease mechanisms as well as possible therapy options. We recognize the complexity of necrotizing enterocolitis research, and therefore we provide you with the option to customize your research requirement whether it is genetically engineered models or any other model, we provide a service that caters to your research needs.

Animal Models for Necrotizing Enterocolitis

• Hypoxia Hypothermia Formula Model
• Hypoxia Formula Model
• Formula Feeding Model
• Paneth Cell Disruption (PCD) Model

• Dextran Sodium Sulfate (DSS) Model
• Trinitrobenzene Sulfonate (TNBS) Model
• Others

Optional Species

Additionally, Protheragen also renders unique services meant to meet defined research needs such as pharmacokinetics and biosafety testing. All of the services and promises seek to support researchers and the pharmaceutical industry's efforts for innovative therapeutics targeting necrotizing enterocolitis and other gastrointestinal disorders. If you wish to find out more about our services, feel free to get in touch to receive quotations and other details.

References

• Colarelli, Andrea Marian et al. "Prevention Strategies and Management of Necrotizing Enterocolitis." Current treatment options in pediatrics 10.3 (2024): 126-146.
• Blum, Laura et al. "Immunological aspects of necrotizing enterocolitis models: a review." Frontiers in immunology 15 (2024): 1434281.
• Hu, Xiaohan et al. "Necrotizing enterocolitis: current understanding of the prevention and management." Pediatric surgery international 40.1 (2024): 32.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.