Therapeutics that are based on cell therapy have changed the treatment paradigm and provide a new approach for fighting infectious diseases. We are one of the global leaders in the infectious disease therapeutics and are aiming to develop novel cell therapy strategies against a wide variety of infectious pathogens. Joining us will ensure that you get strong aid to facilitate the advancement of your research.
Introduction to Cell Therapy
Collection of more pathogens along with the problem of antibiotic resistance when considered together calls for innovative approaches to the treatment of infectious diseases. Modern medicine has advanced in an outstanding manner with the implementation of cell therapy as a novel approach in the treatment. Cell therapy aims at treatment at the cellular level, not just at the symptom level as is typical of most medications.
Fig. 1 CAR T cells targeting infectious diseases. (Seif M, et al., 2018)
How Does Cell Therapy Work?
Cell therapy has the potential to effectively tackle infectious disease by utilizing the distinct functions of living cells. This process includes the introduction of therapeutic cells to the patient which can provide therapeutic effects such as cell replacement, immunomodulation, and paracrine effects.
Cell Replacement
In a few communicable disorders, the cells of the affected individual can be either destroyed by or overrun by the infecting microorganism. The objective of cell therapy is to replace impaired cells with healthy and functional counterparts, restoring normal cellular function and promoting recovery.
Immunomodulation
Atassi and colleagues have synthesized overlapping peptides spanning the entire HC region of BoNT serotype A (BoNT/A). As a result of their analytical work, they determined the peptides that could promote antibody and T-cell responses in mice, which paves the way for a future synthetic vaccine aimed at BoNT intoxication.
Paracrine Effects
The therapeutic cells have the capacity to produce bioactive substances like growth factors, chemokines and cytokines which help in tissue regeneration, inflammation reduction, and immune response modulation. Using the aforementioned paracrine effects, infectious diseases can be treated with the help of cell therapy.
Typical Cell Therapy for Infectious Diseases
A range of methods fall under cell therapy for infectious diseases, a few of which are described below.
CAR-T Cell Therapy
Chimeric antigen receptor T (CAR-T) cell therapy involves genetic alteration of a patient's T cells to make them express a receptor that targets a specific marker present on their infected cells. This unique method has shown significant results in the management of HIV infection and viral therapy.
MSC Therapy
MSCs are multipotential cells that possess immunomodulatory ability which aids in controlling immune responses as well as inflammation. Therapy with MSCs has been utilized in the management of various sorts of infectious illnesses including respiratory infections and viral hepatitis.
NK Cell Therapy
Natural Killer (NK) cells are important aspects of the body’s innate immune system since they are responsible for directly eliminating already infected cells. This form of therapy entails taking NK cells from a donor, multiplying them, and then injecting them into the patient. Satisfactory results were achieved when using NK cell therapy for HCV and HPV infections.
Our Services
With careful cell picking, profound insights into the internal mechanisms, good manufacturing principles, and high safety requirements, our firm provides complete cell therapy development services for infectious diseases. As per the nature of various infectious diseases and end user requirements, we offer varied cell therapy measures in order to expedite the growth of drug development against infectious diseases.
Cell Therapy Development Workflow
Types of Cell Therapy and Applicable Infectious Diseases
Types of Cell Therapy
- Stem Cell Therapy
- T-Cell Therapy
- Dendritic Cell Therapy
- Natural Killer (NK) Cell Therapy
- Mesenchymal Stem Cell (MSC) Therapy
- And More
Applicable Infectious Diseases
Why Choose Us?
Questions & Answer
Q: What information do you need to provide for cell therapy development services?
A: We would need information regarding your target infectious disease or pathogen, patient population, cell source preference, timeline, budget, etc.
Q: What is the cycle and price of cell therapy development services?
A: Our service timelines and fees vary depending on the complexity of the project. We can provide a detailed quote based on your specific requirements.
Our company is dedicated to exploring the potential of multiple cell types for the therapies of infectious diseases. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Seif M, Einsele H, Löffler J. CAR T cells beyond cancer: hope for immunomodulatory therapy of infectious diseases[J]. Frontiers in immunology, 2019, 10: 2711.
- Khoury M, Cuenca J, Cruz F F, et al. Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19[J]. European respiratory journal, 2020, 55(6).
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
