Parasitic infections are caused by parasites that inhabit and breed inside a host's body. These parasites live on a host to extract essential nutrients. We at our company fall among the pioneers in the provision of vaccine development services for parasitic infections combing to integrate research with rational and technological approaches for its prevention and control.
Introduction to Parasitic Infections
In developing nations, such infections pose a huge healthcare issue affecting a major portion of the population and parasitic in origin. These include protozoa, helminths and ectoparasites and are spread through contaminated water, food, soil or when someone comes in physical contact with an infected person. In latest literature, the high rates of the disease burden associated with these parasitic diseases have been documented together with the calls to enhance diagnosis and treatment of these diseases.
Diagnosis Development of Parasitic Infections
| Diagnostic Method |
Description |
Examples |
| Microscopy |
Examination of biological samples using light or fluorescent microscopes to identify morphological features of parasites. |
Detection of trophozoites of Entamoeba histolytica, Giardia duodenalis, and Balantidium coli. |
| Point-of-Care Testing (POCT) |
Tests performed at or near the site of patient care, offering quick and user-friendly diagnostic results without needing complex lab equipment. |
Used for diagnosing malaria, visceral leishmaniasis, and other parasitic infections. |
| Lateral Flow Immunochromatographic Assays (LFIA) |
Simple, quick, and cost-effective tests where a liquid sample migrates through a membrane to identify the presence of specific biomarkers. |
Rida Quick Cryptosporidium/Giardia/Entamoeba Combi kit, immunochromatographic assays for visceral leishmaniasis. |
| Multiplex Molecular Detection Assays |
Simultaneous detection of multiple pathogens using multiplex qPCR technology, allowing differentiation of species and detection of resistance genes. |
Multiplex qPCR for detection of Plasmodium species, gastrointestinal multiplex molecular panels. |
Targets Discovery for Parasitic Infections
One other noteworthy progress in the field of antimalarial drug development is the advent of antimalarial cell-based phenotypic screening. New multicomponent interventions against protozoan parasites have been assisted by studies that employed various omics approaches thus showing great value in drug discovery owing to the use of omics techniques to aid in identifying relevant drug targets against such pathogens.
- Omics-based Methods: These are, for instance, genomics, proteomics, transcriptomics and epigenomics. Aid in Targeted Gene Therapy by finding important genes and key pathways that are amenable to modification.
- Phenotypic Screening: This entails examining huge compound libraries on living parasites to discover compounds that have the desired effect, such as killing the parasite or stopping it from growing.
- Structure-guided Drug Discovery: In this approach, small molecules that are designed and optimized to interact with a specific target protein are developed based on the structural topology modeled of that target protein.
- Chemoproteomics: In this method, chemical probes are used to accomplish the role of determining which proteins a drug is bound to within a parasite, thus aiding in the unfolding of the modes of action.
Fig.1 Overview of the antimalarial target discovery and drug discovery processes. (Cowell, A.N. and Winzeler, E.A., 2019)
Our Services
It is not easy to develop vaccines and therapies that treat parasitic infections, this process is elaborate and time consuming, it should take into account regulatory requirements and conduct a number of tests. We assist biopharmaceutical organizations by delivering end to end therapy and vaccine development services across diverse pathogens.
Types of Parasitic Infections
Why Choose Us?
New variations in technologies can be integrated into therapeutics for parasitic diseases hence giving room for new approaches. We also utilize these technologies within our company to ensure that of our vaccines whose efficacy is improved and made more widely available. Considering the wide variety of services that we offer, feel free to approach us without any hesitation.
References
- Cowell, A.N. and Winzeler, E.A., "Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections." Genome Med, (2019). 11(1): p. 63.
- Kian, M., et al., "Efficacy of Mesenchymal Stem Cells Therapy in Parasitic Infections: Are Anti-parasitic Drugs Combined with MSCs More Effective?" Acta Parasitol, (2022). 67(4): p. 1487-1499.
- Momcilovic, S., et al., "Rapid diagnosis of parasitic diseases: current scenario and future needs." Clin Microbiol Infect, (2019). 25(3): p. 290-309.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
