Fungal infections are known as mycoses and are caused by different types of fungi that can impact certain parts of the body. These are a major global health problem, affecting more than one billion people every year. Our company delivers extensive services tailored to researchers working in the context of infectious disease research, catering to the industry demands of fungal infectious disease therapeutic development.
Overview of Fungal Infections
Fungi are found virtually everywhere on the planet – from dirt to plants, and even animals. Though the number of estimated fungal species could reach around 6 million, only a minuscule portion of them are classified as human pathogens, estimated to be less than 600. Even so, some can cause infections in humans, especially if the immune system is weak. The range is wide too, with the infections varying from being superficial to becoming deep-seated and life-threatening.
Fig.1 Common modes of entry for pathogens. (Otto, W. R., et al., 2020)
Pathogenesis of Fungal Infections
The development of fungal infection requires the host and the fungi to interact. Some of the stages involved in the infection include entry of fungi, overgrowth of fungi, immune evasion, invasion, and a response by the host. Fungal infections are usually classified according to the degree of tissue involvement, such as superficial, cutaneous, or systemic.
Fig.2 Signaling pathways of fungal recognition. (Loh, J. T., et al., 2023)
Diagnostics Development of Fungal Infections
Diagnostics methods targeting fungal infections are evolving with the influx of technology which improves the detection speed and precision. Some of the existing methods include:
Molecular tests
Through PCR and other molecular techniques, pathogenic fungi DNA specifically genetic markers can be detected in a bio-sample. This forms the basis for the rapid determination of pathogenic fungi.
Serological tests
Serological tests based on enzyme-linked immunosorbent assays have increased sensitivity aiding the search for specific antibodies or antigens from specimens thereby increasing the fungal infection diagnostic specifics.
Genetic tests
The development of NGS sequencing technologies has greatly aided in diagnosing the genetics and pathogenicity of infection and hence guiding the appropriate therapeutic and more customized care.
Vaccine and Therapeutics Development of Fungal Infections
| Therapeutics Types |
Names |
Mechanism of Action |
Research Phase |
| Vaccine |
NDV-3A |
Elicit antibody responses that attenuate C. albicans virulence |
Phase II trials |
| PEV7 |
Generate specific IgG and IgA antibodies for protection against vaginal candidiasis |
Phase I trials |
| Inhibitor |
F901318 |
Selective inhibition of the DHODH |
Phase II trials |
| Cytokine |
TNFα |
Enhance immune response |
Preclinical research |
| Antibody |
Mycograb |
Targeting fungal heat shock protein 90 |
Phase III trials |
| Cell therapy |
Adoptive T-cell therapy |
Restore cellular immunity |
Preclinical research |
| CAR T-cell therapy |
Secrete IFNγ to fight fungal infections |
Preclinical research |
Our Services
Our company has an occupation of specialists with vast experience and knowledge as well as providing specialized guidance alongside services, which means that all aspects starting from pathogen and host research to more complex therapeutics, diagnostics, vaccines development, infectious disease models creation, and preclinical studies are under our cover.
Types of Fungal Infections
Therapeutic Development Services of Fungal Infections
Vaccine Development of Fungal Infections
Animal Models Development of Fungal Infections
Models of animals are useful in studying the pathogenesis of fungal infections, immune responses, and in evaluating therapeutics for fungal infections. We provide models of animals suffering from fungal infections to enable investigative research in the areas of disease mechanisms and therapeutic interventions including host-pathogen interactions during fungal infections.
| Types of Model Development |
Routes of Infection |
Animal Species |
| Pathogen infection model, genetically engineering model, humanized model development. |
Intravenous, intraperitoneal, intranasal, intratracheal, or subcutaneous inoculation, etc. |
Mice, rats, rabbits, guinea pigs, hamsters, dogs, cats, toads, bats, and birds, etc. |
With our high service standards and clear grasp of research facilitation, we maintain our reliability as a partner in the infectious disease industry. In case you are interested in our services or you wish to get a quote, please don't hesitate and contact us for further information and assistance.
References
- Loh, Jia Tong, et al. "Fungal infections: Immune defense, immunotherapies and vaccines." Advanced drug delivery reviews 196 (2023): 114775.
- Mendonça, Alexandre et al. "Fungal infections diagnosis - Past, present and future." Research in microbiology 173.3 (2022): 103915.
- Jensen, Henrik Elvang. "Animal models of invasive mycoses." APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 130.7 (2022): 427-435.
- Otto, William R, et al. "Fungal infections in children with haematologic malignancies and stem cell transplant recipients." British journal of haematology 189.4 (2020): 607-624.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
