Genetically Engineering Model Development

Genetic engineering models are extremely important in the study of the progression of the disease, therapeutic objectives, and new treatments creation. Our company specializes in the research and development of genetic engineering models, innovative and novel approaches. A combination of modern technology and a sound scientific approach are employed to develop models that are reflective of the complexities associated with infectious diseases.

What is a Genetically Engineering Model?

Genetic engineering models, or GEMs, are laboratory animals that have been injected with or genetically altered to have disease-prone genes through methods such as gene expression enhancement, gene knock out or knock in. The expectation is that improved GEMs will lead to better understanding of pathogenesis, aid in determining suitable targets for treatment and evaluate drug safety and new therapy effectiveness.

Fig. 1 Rat model constructed using CRISPR-Cas9. (Warner B M., 2021)

Genetically Engineering Models for Infectious Diseases

The market value of genetic engineering models (GEMS) & Services is estimated to value at $3.1991 billion in 2022. This is expected to increase approximately to $5.88155 billion by the year 2032 at a compound annual growth rate of 7.0%. Some of the GEMs for infectious diseases are given below in the table.

Our Services

We have become leaders in the building of infectious disease models using genetic engineering techniques. We follow advanced methods and procedures to ensure the authentication of engineering models.

Workflow of Genetically Engineering Model Development

Target Gene Identification

At the end of our extensive investigation and verifications, our researchers pinpoint major target genes that control the emergence, advancement or response of the disease pathogenesis in a host.

Technology Selection

Choose a suitable technology in genetic modification, for example, CRISPR-Cas9, TALENs, or transgenic technology with respect to the efficiency, specificity, targeting and effectiveness.

Gene Modification

The desired modification is introduced in the embryonic stem cells or the fertilized eggs of the animal models. This may involve gene knock-out, knock-in, point mutation, or other modifications.

Validation and Application

The GEMs are validated in the tremendous way, so they are reliable and reproducible. These models are then used for drug screening, target validation, mechanism exposition, preclinical testing, etc.

Phenotypic Characterization

The GEMs mentioned earlier undergo detailed characterization that allows tracking the effects of such specific genetic alterations. It includes assessment of disease expression, molecular mechanisms, immunity, etc.

Model Generation

Identifying and breeding offspring that possess the target genetic alterations for establishing stable GEM Lines is done by implanting genetically modified eggs, or embryonic stem cells into surrogate mothers.

Optional Types of Animal Models

Optional Species

• Rodents: mice, rats, guinea pigs, rabbits, etc.
• Large Animals: pigs, dogs, sheep, cows, etc.
• Fish and Insects: zebrafish, fruit flies, mosquitoes, etc.
• Non-human Primates: rhesus macaques, cynomolgus macaques, marmosets, etc.

We have developed genetically modified models for various infectious diseases such as bacterial infections, viral infections, parasitic infections, prion diseases and fungal infections. These models can be applied for the pharmacodynamics, pharmacokinetics, and drug safety studies for the therapeutics aimed to treat the infectious diseases.

If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.