In vitro models are indispensable tools in the understanding of the pathogenesis of infectious diseases. Here, we place special focus on creating novel and sophisticated in vitro models for various infectious diseases. By working with us, you will be able to utilize advanced in vitro models to examine pathogen-host interactions, host immune responses, and test out candidate treatments.
Introduction to In Vitro Models of Infectious Diseases
In vitro models of infectious diseases are laboratory systems used to study the complex interactions between the pathogen and its host cells in a setup which is outside the living organism. Such models enable the researchers to analyze the series of molecular and cellular events associated with the infection, replication, immune response, and pathogenesis. By recreating specific aspects of the infection process, in vitro models provide a controlled environment for studying the disease mechanisms and testing potential therapeutics.
Fig. 1 Advanced in vitro models used in research of infectious disease. (Yi H G, et al., 2021)
Typical In Vitro Models of Infectious Diseases
Cell-based Models
Cellular models are essential in the analysis of infectious diseases. Careful cultivation of certain cell types that can be infected allow us to observe of how pathogens enter and replicate as well as the host response. These models are a useful albeit simplistic portrayal of host-pathogen interactions.
Organoid Models
Organoid models are forms of cellular cultures having three dimensions which can be developed from stem cells or cells that are tissue specific. These three-dimensional forms are capable of self-organization and reconstitute the function and tissue architecture of specific organs, thus providing increased detail and relevance for the physiology.
Our Services
The development of in vitro models greatly accelerated research on infectious diseases. Our team is composed of highly qualified specialists with great experience in the field, and is developing modern in vitro models for the study of infectious diseases in urgent need. Our goal is to make these advanced in vitro models available with the intent of shortening the time spent on the discovery and development of therapeutics for various infectious diseases.
Types of In Vitro Models
Cell-based Models
- Primary cells
- Immortalized cell lines
- Induced pluripotent stem cells (iPSC)
- And More
Organoid Models
- Adult stem cell (ASC) source
- Embryonic stem cell (ESC) source
- Patient-derived organoid (POD)
- And More
Workflow of Cell-based Model Development
Cell Selection
Cell Culture
Experimental Design
Infection Operation
Functional Assays
Validation and Optimization
Workflow of Organoid Model Development
Stem Cell Source Selection
Stem Cell Culture
Inducing Organoid Formation
Experimental Design and Infection
Functional Assays
Validation and Optimization
Questions & Answer
Q: What information do you need to provide for in vitro model development services?
A: We need information about your target infectious disease or pathogen, research goals, cell types, culture conditions, test indicators, timeline, budget, etc.
Q: For which infectious diseases can we develop in vitro models?
A: We can provide in vitro model development services for various types of infections, including bacteria, viruses, parasites, fungi, and prions.
Q: What is the cycle and price of in vitro model development services?
A: The timelines and fees for our services are subject to variation based on the complexity of the project. We are able to offer a comprehensive quote tailored to your specific requirements.
Our company specializes in developing excellent in vitro models that solve the complexities associated with infectious diseases while also escalating the drug development process. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Yi H G, Kim H, Kwon J, et al. Application of 3D bioprinting in the prevention and the therapy for human diseases[J]. Signal Transduction and Targeted Therapy, 2021, 6(1): 177.
- Benam K H, Dauth S, Hassell B, et al. Engineered in vitro disease models[J]. Annual Review of Pathology: Mechanisms of Disease, 2015, 10(1): 195-262.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
