Viral Vector Vaccine Development
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Viral Vector Vaccine Development

The cloning of viral vectors has transformed the history of vaccine technology. Our company is dedicated to creating viral vector vaccines to compliment your research projects. We work to advance vaccine technology and make significant jumps in human health by utilizing our expertise and resources in engineering and cutting edge technologies.

What are Viral Vector Vaccines?

Vaccines that utilize viral vectors are unlike traditional vaccines in that they use altered viruses to inject genetic sequences into host cells and show promise in enhancing vaccination methods. These vectors indeed serve as the transporters of genetic information encoding the particular antigen or protein into the cells. Once inside, the host cells use this genetic information to produce the antigen, which triggers an immune response.

COVID-19 viral vector vaccine.Fig. 1 Viral vector vaccine beats COVID-19 in patients with cirrhosis. (Ferreira R D, John B V., 2023)

How Do Viral Vector Vaccines Trigger Immunity?

Use of viral vector vaccines stimulates both innate and adaptive immunities.

Adaptive Immune

The translational DNA encoded in the viral vector makes it possible for the cells of the host organism to synthesize specific proteins which the immune system identifies as an alien substance. Such an event constitutes the beginning of an immune reaction, during which antigen-presenting cells (APCs) are activated, followed by the engagement of T cells with the antigen.

Innate Immune

The viral vector enhances significantly the immune response through the release of cytokines and/interferons and co-stimulatory molecules further aggravating the immune response. Hence, the humoral as well as the cellular immune reactions are initiated and thus complement each other in the protection from the pathogen of interest.

Approved Viral Vector Vaccines

These last years have witnessed the growth of viral vector vaccines as a category of vaccines. Some viral vector vaccines have also been authorized. The following are the authorized viral vector vaccines:

Vaccine Name Targeted Disease Viral Vectors
Oxford-AstraZeneca Vaccine (ChAdOx1) COVID-19 Chimpanzee adenovirus (ChAdOx1)
Sputnik V Vaccine COVID-19 Human adenovirus serotypes
Janssen Vaccine: COVID-19 Adenovirus serotype 26 (Ad26)
Convidecia Vaccine COVID-19 Adenovirus serotype 5 (Ad5)
Zabdeno/Mvabea Ebola Vaccine Ebola Virus Infection The first dose, Zabdeno, utilizes a human adenovirus serotype 26 (Ad26) as the viral vector.
The second dose, Mvabea, uses the same Ad26 vector and carries the genetic code of several Ebola virus proteins.

Our Services

In the field of immunology, the use of viral vector vaccines constitutes an innovative approach The company provides a wide array of services aimed at enhancing viral vector vaccine development including viral vector selection, modification, and assistance with preclinical trial phases, and given our vast experience as well as our unwavering dedication to scientific rigor, we are poised to make great strides in the evolutionary expansion of viral vector vaccine technology.

Viral Vector Vaccine Development Process

Target Identification and Antigen Selection

Comprehension of the biology of the pathogen and its constituent that elicit immune responses allows us to help you in targeting specific diseases or pathogens and in choosing the antigens to be incorporated into the vaccine.

Vector Selection

Viral vectors aid in the transfection of host cells with genetic material encoding antigens, the most common being adenovirus, lentivirus, and vesicular stomatitis virus along with other vectors. The factors influencing the choice of vectors include safety, immunogenicity, and efficacy of delivery of the genetic material to the host cells.

Antigen Design and Vector Engineering

Next, the antigens are inserted into the genomic material of the viral vectors. This may use genetic engineering methods for enhanced expression, stability, and immunogenicity of the antigens. Additionally, the viral vector may be altered to increase safety and decrease replication capacity.

Preclinical Trials

Subsequently, a preclinical study employing animal models or cell cultures for testing is carried out. The studies focus on the safety, immunogenicity, and efficacy of the specific vaccine candidate. They assist in defining the later stages of the clinical trial in terms of the dosage and schedule as well as the formulation.

Advantages of Viral Vector Vaccines

COVID-19 viral vector vaccine.

Questions & Answer

Q: What information do you need to provide for viral vector vaccine development services?

A: We would need information regarding your target pathogen or antigen, desired vaccine characteristics, viral vector preferences, delivery route and formulation, etc.

Q: What is the cycle and price of viral vector vaccine development services?

A: Our service timelines and fees vary depending on the complexity of the project. We can provide a detailed quote based on your specific requirements.

In the event of showing signs of interest in any of the aforementioned services, do not hesitate to contact us for further clarification and or pricing details.

References

  1. Ferreira R D, John B V. Viral Vector Vaccines Are Victorious Against COVID-19 in Patients with Cirrhosis[J]. Digestive Diseases and Sciences, 2023, 68(2): 349-351.
  2. Travieso T, Li J, Mahesh S, et al. The use of viral vectors in vaccine development[J]. npj Vaccines, 2022, 7(1): 75.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.