Preclinical work is extremely important in assessing a drug's safety, efficacy, and its pharmacologic properties. This is especially true for the development of drugs meant to cure infectious diseases, seeing at how much work needs to be done before clinical trials. We are one of the most recognized provider of preclinical research services pertaining to the development of therapies for infectious diseases.
Overview of Preclinical Research
Prior to the commencement of testing the clinical aspects on humans, a detailed series of investigations is conducted in the laboratory which is known as preclinical research. This important step includes evaluating the drug candidates on non-human subjects in order to investigate how the drugs interact in the body as well as its possible toxic effects. The most significant aim of preclinical research is to ensure that there is sufficient evidence supporting safe and effective use of the drug on human subjects.
- Pharmacological Studies
In vitro studies are those experimental pharmacological research practised in a laboratory setting with controlled environments using cells, tissues or biochemical components. The purpose of studying the pharmacological effect of a drug candidate inside a live organism whether animal or human is called in vivo studies. The animal's physiological reactions to the drug are carefully observed to help determine the drug’s effectiveness, dosage level, and possible adverse reactions.
- Pharmacokinetic Analysis
Pharmacokinetics examines a drug candidate's body actions including its absorption, distribution, metabolism, and excretion (ADME). This analysis is essential in outlining the drug's bio behavior, bioavailbility, and its possibility of being retained or eliminated.
- Drug Safety Evaluation
The evaluation of drug candidate safety in the realm of preclinical studies is an important and often complex segment of the entire research process. Comprehensive studies for such evaluations are multi-faceted, encompassing numerous tests and analyses that strive to delineate the safety profile of a drug, its possible toxic effects, and reactions that could be harmful.
Fig.1 Common types of disease models. (Sajjad H., et al., 2021)
The therapeutics of infectious diseases is a global public health problem which developing potent therapies to combat this infection is essential. Preclinical work is important in the selection and progression of therapeutic candidates for treatment of an infectious disease as it enables selection of hits, dosage design, and evaluation of side effects. If you have further inquiry regarding these specific services, the information is available through the link below.
Our Services
Our company appreciates the intricate processes involved in the development of therapies for infectious diseases. We have a specialized team that has vast knowledge on preclinical work in the field of infectious disease. Our scientists apply in vivo and in vitro methods to ensure quality data on the safety and effectiveness of the candidate drugs for novel therapeutics advancement.
Pharmacodynamics
- In Vivo Efficacy Models
-Pathogen Infection Model Development
-Genetically Engineering Model Development
-Humanized Model Development
-Customized Animal Model Development
- Activity Testing
- Drug Resistance Evaleation
Pharmacokinetics
- In Vitro Pharmacokinetics
-Physicochemical Studies
-Metabolism Studies
-Permeability and Transporter Studies
- In Vivo Pharmacokinetics
-Bioavailability
-Quantitative Tissue Distribution
-Metabolite Profiling and Identification
-Drug Excretion
Drug Safety Evaluation
- General Toxicology
- Genetic Toxicology
- Developmental and Reproductive Toxicity
- Immunogenicity and Immunotoxicity
- Local Toxicity
- Phototoxicity
- Tissue Cross-Reactivity
- Toxicokinetics
Preclinical research serves as a fundamental pillar in infectious disease drug discovery and development. With our expertise in infectious disease preclinical research, we aim to contribute to the development of safe and effective therapies. If our comprehensive suite of services has piqued your interest, we earnestly encourage you to reach out to us without any reservations.
References
- Sajjad H., et al. "Cancer models in preclinical research: A chronicle review of advancement in effective cancer research." Animal Models and Experimental Medicine 4.2 (2021): 87-103.
- Loewa Anna, James J. Feng, and Sarah Hedtrich. "Human disease models in drug development." Nature reviews bioengineering 1.8 (2023): 545-559.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
