Infectious diseases are still a menace to world health and require advanced drug discovery and development techniques. To cater for this compelling need, our company has positioned itself as a market leader with regards to the provision of infectious disease model development services.
Model Development in Infectious Diseases
The process of modeling infectious diseases comprises the development of realistic models that reproduce the particulars of human infections. Such models are important for studying disease mechanisms, estimating the safety and effectiveness of potential therapies, and facilitating the drug development processes. Using bioengineering methods like animal modeling, primary cell culture, organoids, organ-on-a-chip, and in vitro tissue cultures, disease models are developed that are as close as possible to human physiology and pathophysiology.
Fig.1 Common types of disease models. (Sajjad H., et al., 2021)
Types of Infectious Disease Models
Cell-based Models
These models involve the culturing of certain cell lines that are known to be infected with the disease. Such models allow for the study of the infection processes and immune response of the host as well as testing the efficacy of antiviral or antibacterial drugs.
Organoid Models
Organoids are self-organizing three-dimensional cell cultures that are derived from induced pluripotent stem cells or other tissue-specific progenitor cells. They faithfully reproduce the architecture and physiology of human tissues and organs.
Animal Models
Mice and rats are popular models because of their close resemblance to humans and the powerful genetic toolbox available. Animals can be infected with various pathogens and studied for disease progression, immune response, and for treatment responses.
Our Services
Here at our company, we are focused on transforming the world of drug discovery and development for infectious diseases by providing exceptional infectious disease model development services. Using our company's know-how and advanced technologies, we provide a tremendous scope of services focused on speeding up the identification and evaluation of potential therapeutics.
Types of Infectious Diseases
Animal Model Development
- Pathogen Infection Model Development
- Genetically Engineering Model Development
- Humanized Model Development
- Customized Animal Model Development
In Vitro Model Development
- Cell-based Model
-Cell line development
-Primary cell development
-iPSC development
- Organoid Model
-Adult stem cell (ASC) source
-Embryonic stem cell (ESC) source
-Patient-derived organoid (POD)
Our team of highly skilled scientists and engineers is experienced in developing bioengineered disease models that closely mimic human infectious diseases. Through careful selection and optimization of culture conditions, we ensure the representation of relevant disease features, including histological similarity, gene regulation patterns, and known drug responses. If our comprehensive suite of services has piqued your interest, we earnestly encourage you to reach out to us without any reservations.
References
- Sajjad H., et al. "Cancer models in preclinical research: A chronicle review of advancement in effective cancer research." Animal Models and Experimental Medicine 4.2 (2021): 87-103.
- Loewa Anna, James J. Feng, and Sarah Hedtrich. "Human disease models in drug development." Nature reviews bioengineering 1.8 (2023): 545-559.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
