The swift and effective diagnosis is a major driving force for the progress in rare kidney disorders research. Here at Protheragen, we are developing advanced diagnostic kits using sophisticated technology and expert skills. Our kits are designed to simplify complicated diagnostic procedures, provide higher experimental precision, and ensure accuracy of results so that our pharmaceutical and academic partners can save their time and money, and expedite project deadlines.
Overview of Diagnostic Kit Development
The rare kidney disorders are particularly difficult to manage because of their genetic and molecular complexities. Accurate diagnosis and more importantly, timely diagnosis is important to commence treatment and organized care. Diagnostic biomarker kits help in the identification of molecular level biomarkers of a disease and hence automate the subsequent diagnosis by the physician. Specialized diagnostic kits will help us comprehend the rare kidney disorders and their pathogenesis which will help us perform more translational research and refine therapeutic approaches.
Fig.1 Identification of nine positive clones expressing monoclonal antibodies (mAbs) against haptoglobin for the development of a haptoglobin-specific sandwich ELISA. (Zheng, X. M., et al., 2021)
Diagnostic Kit for Rare Kidney Diseases
Recent advancements in the area of in vitro diagnostics for rare kidney diseases have been substantial owing to the development of next generation sequencing (NGS) and high-throughput technologies. These technological advancements have made it possible to diagnose certain rare kidney diseases through the identification of associated genetic mutations and molecular markers. With increasing understanding of the underlying molecular mechanisms of these diseases, better management and treatment options continue to emerge.
Table1. Common Diagnostic Kit for Rare Kidney Diseases.
| Kits |
Applications |
Detection Methods |
| Alport Syndrome Genetic Test Kit |
Detects mutations in the COL4A3, COL4A4, and COL4A5 genes associated with Alport syndrome. |
PCR, Next Generation Sequencing (NGS) |
| Polycystic Kidney Disease (PKD) Detection Kit |
Detects mutations in the PKD1 and PKD2 genes, aiding in the diagnosis of autosomal dominant polycystic kidney disease (ADPKD). |
PCR, Genetic Sequencing, NGS |
| Focal Segmental Glomerulosclerosis (FSGS) Kit |
Diagnoses focal segmental glomerulosclerosis (FSGS) by identifying mutations in the NPHS2 gene. |
PCR, Genetic Sequencing |
| Congenital Nephrotic Syndrome Test Kit |
Detects mutations related to congenital nephrotic syndrome, often caused by NPHS1 gene mutations. |
PCR, Genetic Sequencing |
| Cystatin C ELISA Kit |
Measures cystatin C levels in the serum to assess kidney function and monitor disease progression. |
ELISA |
| B2 Microglobulin Detection Kit |
Measures beta-2 microglobulin levels in blood and urine to evaluate kidney function, particularly in rare kidney diseases. |
ELISA, Immunoassay |
Our Services
Protheragen is passionate about developing rare kidney disease diagnostic kits. Our qualified scientists conduct elaborate studies to discover crucial diagnostic markers using cutting edge technology to develop accurate and effective diagnostic tools for these diseases.
Workflow for Diagnostic Kit Development
Proof of Concept and Feasibility
Diagnostic Kit Design
Diagnostic Kit Development Analytical Validation
Optimization & Validation
Diagnostic Kit Types for Rare Kidney Diseases
Protheragen offers specialized kidney organoid model development services tailored to meet various research needs.
- Genetic Testing Kits
- Protein Biomarker Detection Kits
- Enzyme Activity Assay Kits
- Metabolite Measurement Kits
- Point-of-Care Testing (POCT) Kits
- Immunohistochemistry (IHC) Kits
Diagnostic Kit Development for Various Rare Kidney Diseases
Protheragen has the capability to assist your work effortlessly, albeit efficiently, through our tailored diagnostics development services, expertly created to accommodate the exact parameters of your research. Our team confirms that our diagnostic kits are innovative and dependable by crafting precise solutions in accordance with the latest advancements in rare kidney disease research.
Protheragen offers comprehensive, one-stop preclinical development services, specializing in diagnostic kit development for kidney disease research. From diseases model development to drug safety evaluation, our services support every stage of your research process. If you are interested in our services, please don't hesitate to contact us.
References
- Abarghooi-Kahaki, F., et al. "Designing a Diagnostic Kit for Oxalyl Coa Decarboxylase Enzyme by Elisa Method." Immunol Lett 205 (2019): 78-83. Print.
- Zheng, X. M., et al. "Development of a Sensitive and Reliable Elisa Kit of Urinary Haptoglobin to Predict Progress of Diabetic Kidney Disease." Diabetes Metab Res Rev 37.4 (2021): e3432.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
