Nervous System Diseases
The study of rare neurological diseases has posed an arduous challenge for the esteemed pharmaceutical industry. Our company stands tall as a pioneering provider of avant-garde drug and therapy development services dedicated to unraveling the intricacies of the nervous system. Through tireless research and exploration, we strive to forge innovative solutions that will propel your neurological disease investigations forward at an unprecedented pace.
Overview of Nervous System Diseases
The nervous system is a complex network within the human body that consists of the brain, nerves, and spinal cord. Nervous system diseases refer to the disorders and conditions that disrupt the normal functioning of the nervous system. These conditions can have a wide range of effects, including cognitive, physical, and behavioral changes. The realm of nervous system diseases is vast and encompasses various conditions. Let's explore some of the major types:
- Nervous system injuries
- Cerebrovascular disease
- Neurodegenerative diseases
- Headache disorders
- Seizure disorder
- Demyelinating diseases
- Genetic disorders
- Infections
- Cancer
- Congenital conditions
- Neurodevelopmental disorders
Fig.1 Examples of therapies for central nervous system diseases. (Gratpain, Viridiane, et al., 2021)Pathogenesis of Nervous System Diseases
Nervous system diseases can arise from a multitude of factors, with both genetic and environmental influences at play. While the precise mechanisms behind many diseases remain subject to ongoing investigation, researchers have made commendable strides in comprehending the underlying processes.
Genetic Factors
Genetic mutations and abnormalities can contribute to the onset of specific nervous system diseases. For instance, mutations in particular genes have been linked to neurodegenerative disorders like Alzheimer's and Parkinson's disease.
Environmental Factors
Environmental factors, such as exposure to toxins, infections, and traumatic injuries, can also exert an impact on the development of nervous system diseases. For instance, head injuries can give rise to enduring neurological ramifications, such as chronic traumatic encephalopathy.
Diagnostics of Nervous System Diseases
- Molecular Diagnostics
Molecular diagnostics, including genetic testing and biomarker analysis, provide valuable information about the underlying causes and progression of nervous system diseases.
Table 1 Cases of targeted therapies for neurological disorders. (McCartan, Robyn, et al., 2023)
| Condition | Drug name | Target | Delivery method |
|---|---|---|---|
| Spinal muscular atrophy | Nusinersen (Spinraza) | SMN2 | IT |
| Batten's disease | Milasen | ATXN2 | IT |
| Amyotrophic lateral sclerosis | Tofersem (Qalsody) | SOD1 | IT |
Our Services
At our company, we develop diagnostics as well as innovative therapies, including small molecule drug, cell therapy, gene therapy, therapeutic antibody, therapeutic peptide, and therapeutic protein, to address the challenges posed by neurological diseases. Through our ongoing research and development efforts, we aim to help global pharmaceutical companies develop drugs and therapies for neurological diseases.
Types of Nervous System Diseases
A-BC-D
F-L
M-N
P-W
With our cutting-edge research, state-of-the-art facilities, and dedicated team, our company is at the forefront of nervous system disease therapy and animal model development. Our company's expertise in rare disease preclinical research enables us to provide one-stop drug and therapeutic development services for rare neurological systems, including pharmacokinetics studies and drug safety evaluation.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Gratpain, Viridiane, et al. "Extracellular vesicles for the treatment of central nervous system diseases." Advanced drug delivery reviews 174 (2021): 535-552.
- McCartan, Robyn, et al. "Nucleic acid-based therapeutics for the treatment of central nervous system disorders." Frontiers in genetics 14 (2023): 1250276.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.