Antibody Production Service
With the development of biotechnology, antibody therapy has been widely used in the treatment of rare diseases due to its good efficacy and high safety. Our company provides high-quality antibody production services and has a variety of antibody production platforms to help you make progress in the development of antibody therapy for rare diseases.
Types of Antibody Therapies
Antibody therapy is mainly divided into monoclonal antibody and polyclonal antibody. The monoclonal antibody is secreted by a single B lymphocyte, which is highly specific and can identify pathogens more accurately. The polyclonal antibody is composed of a variety of antibodies, which can recognize multiple antigen epitopes and improve the sensitivity of immune determination. It is widely used in the diagnosis and research of disease.
Fig.1 Workflow for scFvs conversion into full mAbs (Zambrano, Nicola, et al. 2022)
When selecting the appropriate antibody clone for rare disease antibody therapy, several key parameters must be considered. The following table compares the advantages and drawbacks of producing monoclonal antibodies and producing polyclonal antibodies.
| Types | Advantages | Drawbacks |
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| Monoclonal antibodies |
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| Polyclonal antibodies |
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Our Services
Our company provides comprehensive customized antibody production services, including a variety of monoclonal antibodies and polyclonal antibody-related production services, to meet your research needs in antibody therapy.
- Monoclonal Antibodies Production Service
We have a proven track record in developing rare disease monoclonal antibodies, utilizing a range of proprietary technologies to maximize your chances of generating highly specific and high-affinity antibodies. Our custom antibody service is tailored to accommodate projects of varying complexity. Our services include but are not limited to:
| Service | Content |
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Antibody formats: Fab, scFv, sdAb/VHH, Fc fusion proteins, chimeric antibodies, and bispecific antibodies. |
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Stable cell lines and selection systems: CHO, HEK, BHK, among others. |
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Production Method: Medium With serum, Serum-free Medium, Animal-free Medium |
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The use of mammalian expression systems offers a rapid and reliable solution for producing dozens or even hundreds of antibodies. |
- Polyclonal Antibody Production Service
Our comprehensive polyclonal antibody services include the production of custom polyclonal antibodies in SPF animals. Our company provides one-stop solutions for your custom polyclonal antibody production, taking your project all the way from animal immunization to antibody purification and QC analysis.
| Service | Content | |||
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| Host for polyclonal antibody production |
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| Polyclonal antibody purification |
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Antibody Production Workflow
Expression vector construction
Gene expression
Antibody purification
Quality control
Our company has the capabilities and resources to provide professional communication and problem-solving support to ensure that we can quickly respond to the changing needs of your rare disease therapy research projects. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Zambrano, Nicola, et al. "High-throughput monoclonal antibody discovery from phage libraries: challenging the current preclinical pipeline to keep the pace with the increasing mAb demand." Cancers 14.5 (2022): 1325.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.