Central Nervous System Evaluation
Central nervous system (CNS) evaluation can help determine the potential adverse effects of drugs on the CNS and is an important step in the safety evaluation of new drugs. With years of experience in rare disease therapy research and development, our company's central nervous system evaluation services are becoming more and more mature, and we provide end-to-end high-quality services to promote the research and project goals of our global clients. Whatever your requirements, we will work closely with you to develop a custom solution.
Introduction to Central Nervous System Evaluation
The ICH S7A safety pharmacology guidance document states the requirement to evaluate the effects of drugs on the central nervous system, including effects on motor activity, behavioral changes, coordination, sensory/motor reflex responses, and body temperature. The central nervous system controls the body's use, thinking, emotions, consciousness, immune system, and neuroendocrine system, and is important for maintaining life. Therefore, during drug development, attention needs to be paid to the side effects of drugs on the central nervous system. In addition, CNS evaluation can help determine the safe dosage range of drugs used in the CNS.
Fig.1 Examples of CNS safety pharmacology evaluation. (Jongchanapong, A., et al., 2023) Methods of Central Nervous System Evaluation
Irwin Test
The Irwin Test is an observational method that allows for multiparametric assessment of nervous system function, commonly performed in rodents. Parameters assessed by the Irwin Test include, but are not limited to, convulsions, death, changes in coordination and balance, fear, aggression, analgesia and reflexes.
Functional Observation Battery
Functional Observation Battery (FOB) is optimized and developed by Irwin Test . Experimenters observe changes in body behavior, sensation/reflection and other functions, quantitatively score corresponding indicators, and evaluate the impact of drugs on the central and peripheral nervous systems of the body.
Our Services
- In Vivo Central Nervous System Evaluation
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- Content of Central Nervous System Evaluation
Based on the pharmacological effects and chemical structure of the drug and the expected adverse reactions, our company provides central nervous system evaluation services. Follow-up central nervous system evaluation such as learning and memory, behavioral pharmacology, neurochemistry, ligand-specific binding, visual, auditory, and/or electrophysiology examinations can be performed to further evaluate CNS effects. We provide CNS evaluation services including but not limited to:
- Functional observation battery (FOB)
- Irwin Test
- Body temperature monitoring
- Large animal neurological evaluations
- Activity meter test
- Rotarod test
- Electroconvulsive shock (ECS) threshold and PTZ seizure tests
- Hot plate test
Why Choose Us?
- Providing standardized upstream platform solutions
- The rich experience accumulated in successful cases of new drug development
- Cost-effective compared to other companies
- High-quality products and services
- Expertise and experience in the industry
- Reliable and trusted partner
Project Workflow
With extensive experience in rare disease therapy research and development, our company provides customers with a cost-effective and convenient solution. Our central nervous system evaluation service is a simplified workflow by a group of specially trained and professional scientists. we have the capabilities and resources to provide professional communication and problem-solving support to ensure that we can quickly respond to the changing needs of your rare disease research projects. If you are interested in our services, please feel free to contact us for more information.
Reference
- Jongchanapong, A., et al. "Antinociceptive efficacy of Clerodendrum petasites S. Moore, a Thai medicinal plant, and its CNS safety profiles." Journal of Traditional and Complementary Medicine 13.1 (2023): 81-92.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.