Curling ulcer is an acute ulceration of the stomach or duodenum also known as duodenal ulcer, which includes ulcerative lesions in the gastric or duodenal mucosal lining that occurs in critically injured or severely ill individuals. As one of the foremost research service providers, Protheragen develops and provides proprietary preclinical drug development solutions for Curling ulcers.

Overview of Curling Ulcer

Curling ulcers are often referred to under the term stress ulcer owing to their shared characteristics with the acute ulcers seen after significant surgeries, mechanical ventilation, severe traumatic shock, or sepsis. While this condition is not common, it imposes a significant burden in terms of morbidity and mortality due to its unpredictable symptoms and rapid, potentially harmful progression.

Fig.1 Characteristics of duodenal ulcer individuals. (Chen, Y. Y., et al., 2024)

Pathogenesis of Curling Ulcer

Stress ulceration occurs from damaging the mucosal barrier due to systemic stress, leading to multiple superficial erosions of the gastric mucosa. Possibilities of pathological changes leading to ulceration include damage to the mucosal barrier. Increased uremic toxins or bile salt from refluxed volume due to critical illness denudes the mucosal glycoprotein. It is also believed that increased secretion of gastric acid in stress conditions due to increased secretion of gastrin hormone is responsible for stress ulceration.

Therapeutics Development for Curling Ulcer

Disclaimer: Protheragen focuses on providing preclinical research services. This table is for information exchange purposes only. This table is not a treatment plan recommendation. For guidance on treatment options, please visit a regular hospital.

Our Services

Utilizing the latest technologies and scientific innovations, we conduct specific drug discovery projects that search for new Curling ulcer targets and therapeutics. Furthermore, our tailored disease model development services offer pharmaceutical companies and researchers precise tools for preclinical drug screening, effectiveness studies, and mechanistic research.

Therapeutic Development Services

Therapeutic Development Services

• Small Molecule Drug
• Cell Therapy Development
• Gene Therapy Development
• Therapeutic Antibody

• Therapeutic Peptide
• Therapeutic Protein
• Microbiome Therapeutic
• More

Animal Model Development Services

Animal models in drug discovery aid in testing possible medicines in an in vivo setting before the human trial phases. Our animal model development services assist scientists and researchers in the Curling ulcer disease therapy research for in vivo preclinical drug testing, efficacy assessment, and mechanistic studies.

Radiation-induced Model

An animal model of chronic duodenal ulcer, where the ulcer is formed through radiation of the lower mediastinal region of mice via a single dose x-ray.

Cysteamine-induced Model

Cysteamine impairs the barrier of the duodenal mucosa and increases gastric acid secretion, thus facilitating ulcer development by various mechanisms.

Protheragen's multidisciplinary team collaborates seamlessly to provide comprehensive services including pharmacokinetic research and biosafety evaluation services. We are committed to scientific excellence and innovation, harnessing state-of-the-art methodologies to drive advancements in understanding and treating Curling ulcer disease. If you are interested in our services, please contact us for more details.

Reference

• Chen, Yang-Yuan et al. "A Rare Cause of Duodenal Ulcer." Gastroenterology 166.4 (2024): 568-571.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.