Induced Disease Model Development Service
Induced disease models are experimental systems that replicate specific disease conditions in animals, allowing researchers to gain valuable insights into rare disease drug research. Our company recognizes the importance of studying rare diseases and offers specialized services in the development of induced disease models for these conditions. Our team of highly skilled scientists and technicians ensures the highest standards of quality and accuracy in all aspects of induced disease model development.
Introduction to Induced Disease Model
Induced disease models involve the experimental induction of a disease phenotype in animals using various techniques. These models can be created through pharmacological or chemical interventions, where specific drugs or toxins are administered to mimic rare disease pathology selectively. These external stimuli inflict damage on the animals' tissues, organs, or entire bodies, resulting in functional, metabolic, or morphological changes that resemble human diseases. By introducing external factors, these models can mimic the key features of human diseases, providing a platform for studying disease pathogenesis and evaluating potential rare disease therapies.
Fig.1 Schematic diagram of animal model development. (Hasan M. M., et al., 2018)Induced Disease Model for Rare Diseases
Lesion-Induced Models
Lesion-induced models involve the creation of lesions in specific areas of the animal's body to induce disease. Lesions can be mechanical or electrolytic, targeting specific organs or systems. Lesion-induced models have been used for studying diseases such as Alzheimer's disease and diabetes mellitus, where lesions are made in the cholinergic centers of the basal forebrain and pancreas, respectively.
Stress-Induced Models
Stress-induced models involve the application of chronic mild stress through environmental stimuli. These models are particularly relevant for behavioral sciences and can be used to generate models for pain disorders and depression. By exposing animals to various stressors, researchers can investigate the underlying mechanisms and develop therapeutic interventions.
Biological Molecule-Induced Models
Another approach to creating induced disease models is the application of specific biological molecules or entities to trigger the induction of disease. For instance, the injection of amyloid-β in animals can produce an Alzheimer's disease-like phenotype, while the application of scrapie-associated prion protein is extensively used to generate animal models of prion diseases.
Our Services
By leveraging the latest technologies, we provide induced disease models that faithfully reproduce key features of rare diseases. These models are indispensable tools for conducting drug safety evaluation, pharmacokinetics research, and accelerating the drug discovery process. We collaborate closely with our clients, offering custom-tailored study designs, flexible approaches, and expert advice to meet their research objectives.
- Animal Species for Model Development
-Mouse
-Rat
-Rabbit-Pig
-Dog-Monkey
-Cat-Zebrafish
-Others - Methods of Induced Disease Model Development
- Chemical induction: alkylating agents, nitrosamines, aromatic amines, cadmium, and arsenic
- Radiation induction: ionizing radiation, ultraviolet irradiation
- Physical agonist induction: asbestos fibers induce cancer
- Special diet induction: high fructose/sucrose or high/low-fat diet
- Virus induction: AAV2 hA53T α-synuclein, AAV9 TDP-43, and AAV9 Tau P301
- Types of Induced Disease Model Development
Why Choose Us?
Our company is an integrated CRO with the ability to offer professional communication and problem-solving assistance. We have the capabilities and resources to promptly address any evolving requirements related to your rare disease research projects. Our services encompass extensive development of induced disease models, catering to both established biopharmaceutical companies and emerging scientific research institutions. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Hasan M. M., et al. "Animal models and natural products to investigate in vivo and in vitro antidiabetic activity." Biomedicine & Pharmacotherapy 101 (2018): 833-841.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.