Humanized Model Development

The rapidly growing field of humanized modelling has proven to be invaluable in the study of infectious diseases. We strive to provide the best quality humanized models by working alongside researchers, educational institutions, and drug companies. To guarantee reproducible and dependable models that are tailored to meet their unique scientific questions, we collaborate extensively with our partners to create and design models in accordance with their research requirements.

Introduction to Humanized Models

Humanized models are systems where animals are altered genetically or transplanted with human cells, tissues or genes to approximate a certain aspect of human physiology or pathology. It is built to look like certain features of human biology like immune responses, organ function, disease predisposition and even disease itself to enable the study of human sicknesses and the evaluation of proposed treatment methods in a more applicable situation.

Fig. 1 Humanized mouse models of Epstein-Barr virus (EBV) infection. (Fujiwara S, et al., 2015)

Application of Humanized Models in Infectious Disease Research

Humanized models have been widely used in the area of infectious disease to assess the pathogenesis of human pathogens, determine vaccine candidates, evaluate antiviral agents, and study the immune response of the host. These models serve as an outstanding platform for understanding the intricate mechanisms of pathogen and human immune interactions; thus, gaining an understanding of disease evolution and developing suitable therapies.

Our Services

The development of humanized models is important in furthering our comprehension of infectious disorders while fast-tracking the clinical implementation of research outcomes. Stem cell technologies, tissue engineering and gene editing tools allow our company to develop humanized models with increased human likeness. It has become imperative to adopt a strict development process to ensure these humanized models' reliability and reproducibility.

Humanized Model Development Process

Drug Target Identification

Hit Discovery

Lead Optimization

Antipathogen Activity Evaluation

Preclinical Studies

Formulation Development

Optional Species

We create humanized models for a range of infectious diseases including bacterial and viral infections, parasitic, fungal and prion diseases. These models simulate certain human physiological characteristics and disease phenomenology, thus providing an excellent platform for the preclinical investigation of the therapeutic pathways. This includes pharmacodynamics, pharmacokinetics studies and safety testing of the drugs.

If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.