A firm comprehension of the interactions between hosts and pathogens is a prerequisite to developing efficient drug therapies. Our company is at the forefront of pathogen and host research services, dedicated to advancing infectious disease drug discovery and development.
Host-Pathogen Interaction
Host-pathogen interaction incorporates the processes through which pathogens maintain themselves within host organisms and its phytological consequences on both the pathogen and the host. While the term is often used, for most purposes, in the context of disease causing microbes, it must be understood that not all pathogens result to a disease in all hosts. For this reason, the definition has been broadened to encompass known pathogens and their behavior within the hosts without regard to their pathogenicity.
Fig.1 Interaction of various pathogen types. (Soare A. Y., et al., 2021)
Pathogen and Host Research in Infectious Diseases
Pathogen and host research is a multifaceted field that encompasses the study of both the genetic makeup of pathogens and the host genomes.
Pathogen Genomes
Research into host genetics and infectious diseases has led to a deeper understanding of the importance of genetic variation within the population. For instance, the specific Covid-19 host genetic researches conducted were able to carve the particular genes which increased the odds of severe infection. These findings are useful not only in understanding the pathophysiology of the disease but also in creating drugs that are targeted to these specific genes.
Host Genomes
Genetic attributes of the host can safeguard them against some infections. For example, the HBB gene is linked to lower susceptibility to malaria while the FUT2 gene offers some protection against norovirus infection. These factors allow for exploration into disease resistance and preventive measures.
Our Services
Our company provides thorough research services on pathogen and host interactions using the latest developments in bioinformatics and genomics. Our knowledge, paired with sophisticated technologies, allows us to analyze the complexities of host-pathogen interactions, and participate in the designs of novel therapies for various infectious diseases.
- Genomic Surveillance and Variant Analysis
Our surveillance and analysis systems enable us to capture emerging variants of a pathogen along with its tracking, offering critical clues toward understanding their evolution and potential impacts on the host's vulnerability. A genomic analysis of the pathogens and the respective hosts provides markers of aggression and responsiveness towards treatment.
- Host Genomics and Susceptibility Studies
Through our host genomics research, we aim to explain the host side genetics that allows survival of different infectious diseases. The genetic variants of concern that might increase or decrease the susceptibility to certain pathogens can be explored in large cohort studies.
- Host-Pathogen Interaction Studies
Our company applies innovative and advanced approaches to study how pathogens invade the host's cellular machinery to cause infection and evade immune response. Understanding these mechanisms will help identify drugable targets and aid in developing new therapeutic modalities.
In addition, we are pleased to provide a wide range of services to meet your needs.
Pathogen Research Services
- Pathogen Biology
- Pathogenic Mechanism
Host Reaction Research Services
- Host Susceptibility Research
- Host Immune Response
- Pathological and Behavioral Changes
Next-generation Sequencing Services
- Whole Genome Sequencing
- Whole Exome Sequencing
- RNA Sequencing
- Epigenomics Sequencing
- Proteomics Sequencing
- Microbiome Sequencing
- DNA Methylation Sequencing
Utilizing our strengths in studying pathogens and hosts, we can optimally assist you in designing vaccine therapies. Our knowledge in the interdependent biology of hosts and pathogens enables us to develop and refine vaccines that capture and eliminate these threats.
These services are important for working on new drug development for infectious diseases. Targeted treatment strategies can be designed if there is sufficient knowledge of host genomics, host-pathogen interactions, and the associated genetic markers linked with susceptibility and therapeutic response. If you found our wide array of services interesting, we encourage you to contact us without reservation.
References
- Soare Alexandra Y., et al. "P2RX7 at the host-pathogen interface of infectious diseases." Microbiology and Molecular Biology Reviews 85.1 (2021): 10-1128.
- Milne Richard, and Christine Patch. "Ethical challenges associated with pathogen and host genetics in infectious disease." The New Bioethics 29.1 (2023): 24-36.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
